Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated...

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Vydáno v:Nature immunology Ročník 23; číslo 5; s. 658 - 659
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Nature Publishing Group 01.05.2022
Témata:
CD8 antigen
Cell cycle
Cell growth
Cell proliferation
Division of labor
Genetic engineering
Heterogeneity
Immunological memory
Immunology
Infections
Lymphocytes
Lymphocytes T
Memory cells
Population
Stem cells
ISSN:1529-2908, 1529-2916, 1529-2916
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Shrnutí:A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.
Bibliografie:ObjectType-Article-1
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-022-01169-3