Transcriptional state and function of CD8 + memory T cells is linked to past proliferation

A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature immunology Jg. 23; H. 5; S. 658 - 659
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.05.2022
Schlagworte:	CD8 antigen Cell cycle Cell growth Cell proliferation Division of labor Genetic engineering Heterogeneity Immunological memory Immunology Infections Lymphocytes Lymphocytes T Memory cells Population Stem cells
ISSN:	1529-2908, 1529-2916, 1529-2916
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!