The Multifaceted Role of Regulatory T Cells in Breast Cancer
The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells strive to impair effective immunity and promote tumor progre...
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| Published in: | Annual review of cancer biology Vol. 5; p. 291 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
04.03.2021
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| Subjects: | |
| ISSN: | 2472-3428, 2472-3428 |
| Online Access: | Get more information |
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| Summary: | The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells strive to impair effective immunity and promote tumor progression. Of these, regulatory T cells (T
), the gatekeepers of immune homeostasis, emerge as multifaceted players involved in breast cancer. Intriguingly, clinical observations suggest that blood and intratumoral T
can have strong prognostic value, dictated by breast cancer subtype. Accordingly, emerging preclinical evidence shows that T
occupy a central role in breast cancer initiation and progression and provide critical support to metastasis formation. Here, T
are not only important for immune escape but also promote tumor progression independent of their immune regulatory capacity. Combining insights into T
biology with advances made across the rapidly growing field of immuno-oncology is expected to set the stage for the design of more effective immunotherapy strategies. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2472-3428 2472-3428 |
| DOI: | 10.1146/annurev-cancerbio-042920-104912 |