The Multifaceted Role of Regulatory T Cells in Breast Cancer

The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells strive to impair effective immunity and promote tumor progre...

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Veröffentlicht in:Annual review of cancer biology Jg. 5; S. 291
Hauptverfasser: Kos, Kevin, de Visser, Karin E
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 04.03.2021
Schlagworte:
breast cancer
immunosuppression
regulatory T cell
tumor microenvironment
metastasis
ISSN:2472-3428, 2472-3428
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Zusammenfassung:The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells strive to impair effective immunity and promote tumor progression. Of these, regulatory T cells (T ), the gatekeepers of immune homeostasis, emerge as multifaceted players involved in breast cancer. Intriguingly, clinical observations suggest that blood and intratumoral T can have strong prognostic value, dictated by breast cancer subtype. Accordingly, emerging preclinical evidence shows that T occupy a central role in breast cancer initiation and progression and provide critical support to metastasis formation. Here, T are not only important for immune escape but also promote tumor progression independent of their immune regulatory capacity. Combining insights into T biology with advances made across the rapidly growing field of immuno-oncology is expected to set the stage for the design of more effective immunotherapy strategies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2472-3428
2472-3428
DOI:10.1146/annurev-cancerbio-042920-104912