Clustering of Pattern Recognition Receptors for Fungal Detection e1003873

[...]it has been reported that DC-SIGN synergizes TLR signaling through RAF1, a serine/threonine kinase, which induces phosphorylation of the p65 subunit of NFκB, followed by prolonged and enhanced transcription of Il10 by NFκB activation [14]. [...]OPN-deficient immunocompromised mice are extreme...

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Bibliographic Details
Published in:PLoS pathogens Vol. 10; no. 2
Main Authors: Inoue, Makoto, Shinohara, Mari L
Format: Journal Article
Language:English
Published: San Francisco Public Library of Science 01.02.2014
Subjects:
Chemokines
Cytokines
Fungal infections
Fungi
Immune system
Kinases
Ligands
Lipids
Lymphocytes
Lymphoma
Pattern recognition
Phosphorylation
Proteins
ISSN:1553-7366, 1553-7374
Online Access:Get full text
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Summary:[...]it has been reported that DC-SIGN synergizes TLR signaling through RAF1, a serine/threonine kinase, which induces phosphorylation of the p65 subunit of NFκB, followed by prolonged and enhanced transcription of Il10 by NFκB activation [14]. [...]OPN-deficient immunocompromised mice are extremely susceptible to opportunistic infection by Pneumocystis [10]. iOPN is known to co-localize with actin and induces cytoskeletal rearrangement [18], [19].
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ISSN:1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003873