IMMUNOHISTOCHEMICAL STUDY OF DEPIGMENTED SKIN OF VITILIGO PATIENTS

Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has been shown that the cells containing melanocytic cell marker TRP1 are localized both in macular and perimakular areas. Within the macula of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:T͡S︡itologii͡a Ročník 59; číslo 1; s. 19
Hlavní autoři: Revishchin, A V, Panteleev, D Yu, Zakharova, L G, Lomonosov, K M, Pavlova, G V
Médium: Journal Article
Jazyk:angličtina
ruština
Vydáno: Russia (Federation) 2017
ISSN:0041-3771
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has been shown that the cells containing melanocytic cell marker TRP1 are localized both in macular and perimakular areas. Within the macula of depigmentation all TRP1 positive cells are in close contact with the basement membrane. In perimakular areas many cells that have lost contact with the basement membrane, were localized deep in the epidermis. About 92 % of TRP1 positive perimakular cells were also vimentin positive. Vimentin positive cells were numerous in perimakular areas but missing in the macula of depigmentation. Dense groups of cells immunopositive for transcription factor Snail, known as inductor of epithelial-mesenchymal transition, were localized in perimakular areas in close proximity to the macula depigmentation border. Such cells were extremely rare within the macula of depigmentation. There is reason to assume that an intensive process, which is similar to the epithelial-mesenchymal transition, might be the cause of melanocyte death in perimakular field, and thus prevents repigmentation of depigmented areas.
AbstractList Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has been shown that the cells containing melanocytic cell marker TRP1 are localized both in macular and perimakular areas. Within the macula of depigmentation all TRP1 positive cells are in close contact with the basement membrane. In perimakular areas many cells that have lost contact with the basement membrane, were localized deep in the epidermis. About 92 % of TRP1 positive perimakular cells were also vimentin positive. Vimentin positive cells were numerous in perimakular areas but missing in the macula of depigmentation. Dense groups of cells immunopositive for transcription factor Snail, known as inductor of epithelial-mesenchymal transition, were localized in perimakular areas in close proximity to the macula depigmentation border. Such cells were extremely rare within the macula of depigmentation. There is reason to assume that an intensive process, which is similar to the epithelial-mesenchymal transition, might be the cause of melanocyte death in perimakular field, and thus prevents repigmentation of depigmented areas.
Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has been shown that the cells containing melanocytic cell marker TRP1 are localized both in macular and perimakular areas. Within the macula of depigmentation all TRP1 positive cells are in close contact with the basement membrane. In perimakular areas many cells that have lost contact with the basement membrane, were localized deep in the epidermis. About 92 % of TRP1 positive perimakular cells were also vimentin positive. Vimentin positive cells were numerous in perimakular areas but missing in the macula of depigmentation. Dense groups of cells immunopositive for transcription factor Snail, known as inductor of epithelial-mesenchymal transition, were localized in perimakular areas in close proximity to the macula depigmentation border. Such cells were extremely rare within the macula of depigmentation. There is reason to assume that an intensive process, which is similar to the epithelial-mesenchymal transition, might be the cause of melanocyte death in perimakular field, and thus prevents repigmentation of depigmented areas.Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has been shown that the cells containing melanocytic cell marker TRP1 are localized both in macular and perimakular areas. Within the macula of depigmentation all TRP1 positive cells are in close contact with the basement membrane. In perimakular areas many cells that have lost contact with the basement membrane, were localized deep in the epidermis. About 92 % of TRP1 positive perimakular cells were also vimentin positive. Vimentin positive cells were numerous in perimakular areas but missing in the macula of depigmentation. Dense groups of cells immunopositive for transcription factor Snail, known as inductor of epithelial-mesenchymal transition, were localized in perimakular areas in close proximity to the macula depigmentation border. Such cells were extremely rare within the macula of depigmentation. There is reason to assume that an intensive process, which is similar to the epithelial-mesenchymal transition, might be the cause of melanocyte death in perimakular field, and thus prevents repigmentation of depigmented areas.
Author Lomonosov, K M
Pavlova, G V
Revishchin, A V
Panteleev, D Yu
Zakharova, L G
Author_xml – sequence: 1
  givenname: A V
  surname: Revishchin
  fullname: Revishchin, A V
– sequence: 2
  givenname: D Yu
  surname: Panteleev
  fullname: Panteleev, D Yu
– sequence: 3
  givenname: L G
  surname: Zakharova
  fullname: Zakharova, L G
– sequence: 4
  givenname: K M
  surname: Lomonosov
  fullname: Lomonosov, K M
– sequence: 5
  givenname: G V
  surname: Pavlova
  fullname: Pavlova, G V
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30188099$$D View this record in MEDLINE/PubMed
BookMark eNo1j0trg0AYRWeR0qRp_kJx2Y3wjeNkZpapGh3qI-Ck0JWMZoQUX9W6yL9vQtPVhXsPB-4TWnR9ZxZoBeBimzCGl2gzTV8AgIG4lLNHtCSAOQchVuhNJskxzSKZq8yLgkR6u9jK1dH_tLK95QcHGSZBqgLfyt9leus-pJKxDDPrsFPyOuXP6KHWzWQ291wjtQ-UF9lxFt509kC3wmalU3JqOCtJ7VLGNKvdUjChHS10XdFKcOCEaOHWtOLVFigDXBLNBaFaw8lZo9c_7TD237OZfor2PFWmaXRn-nkqHAxAHI5dekVf7uhctuZUDOO51eOl-L_t_ALZxU4G
ContentType Journal Article
DBID NPM
7X8
DatabaseName PubMed
MEDLINE - Academic
DatabaseTitle PubMed
MEDLINE - Academic
DatabaseTitleList PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Biology
ExternalDocumentID 30188099
Genre Journal Article
English Abstract
GroupedDBID ALMA_UNASSIGNED_HOLDINGS
F5P
NPM
RUPBI
SV3
VCL
VIT
7X8
ID FETCH-LOGICAL-p569-7b2b85e87b3f4577a7f4b979a2a9afc5c980833a94f5c8c605701b3a8935aa0d2
IEDL.DBID 7X8
ISSN 0041-3771
IngestDate Thu Oct 02 07:39:44 EDT 2025
Wed Feb 19 02:42:00 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
Russian
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-p569-7b2b85e87b3f4577a7f4b979a2a9afc5c980833a94f5c8c605701b3a8935aa0d2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 30188099
PQID 2100328145
PQPubID 23479
ParticipantIDs proquest_miscellaneous_2100328145
pubmed_primary_30188099
PublicationCentury 2000
PublicationDate 2017
20170101
PublicationDateYYYYMMDD 2017-01-01
PublicationDate_xml – year: 2017
  text: 2017
PublicationDecade 2010
PublicationPlace Russia (Federation)
PublicationPlace_xml – name: Russia (Federation)
PublicationTitle T͡S︡itologii͡a
PublicationTitleAlternate Tsitologiia
PublicationYear 2017
SSID ssj0001034587
Score 2.014792
Snippet Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 19
Title IMMUNOHISTOCHEMICAL STUDY OF DEPIGMENTED SKIN OF VITILIGO PATIENTS
URI https://www.ncbi.nlm.nih.gov/pubmed/30188099
https://www.proquest.com/docview/2100328145
Volume 59
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA7oFHzxfpk3KvhabJtkSZ5kulvBtYVVmU8lSRvwpZubE_z3nrQdPgmCL31IKYST5JzvOynfh9Ct5-W4U9Dc5dhXLlHcuApQrms8JUwBBdkTpjKbYFHEp1ORNA23ZfNb5TonVok6n2nbI78DamKl33xC7-fvrnWNsrerjYXGBmphgDJ2V7Mp_-mxeJhQXstmEh_OEvN_B5JVQRns_Xcq-2i3gZJOt177A9QqSmexOkTbtb_k1xF6CMfj5ygehZM0XmsfOBYDvjrxwOn1k3Botfz7PWcCLN6OvYRp-BQOYyfppiG8mhyjdNBPH0duY5rgzmlHuEwFitOCM4UNoYxJZogSTMhACmk01YID6MJSEEM110BmmOcrLAG2UCm9PDhBm-WsLM6QkzMDXC3XHSE9ooGIaFZQ6whDcomB2bbRzTo8GexJe9Egy2K2WmY_AWqj0zrG2bwWz8ggoUDKEOL8D19foJ3AVtGq43GJWgZOZHGFtvTnx9tycV0tNjyjZPwNGMGvGQ
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IMMUNOHISTOCHEMICAL+STUDY+OF+DEPIGMENTED+SKIN+OF+VITILIGO+PATIENTS&rft.jtitle=T%CD%A1S%EF%B8%A1itologii%CD%A1a&rft.au=Revishchin%2C+A+V&rft.au=Panteleev%2C+D+Yu&rft.au=Zakharova%2C+L+G&rft.au=Lomonosov%2C+K+M&rft.date=2017-01-01&rft.issn=0041-3771&rft.volume=59&rft.issue=1&rft.spage=19&rft_id=info%3Apmid%2F30188099&rft_id=info%3Apmid%2F30188099&rft.externalDocID=30188099
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0041-3771&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0041-3771&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0041-3771&client=summon