Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes

The Na -HCO cotransporter NBCn1 (SLC4A7) is up-regulated in breast cancer, important for tumor growth, and a single nucleotide polymorphism (SNP), rs4973768, in its 3' untranslated region (3'UTR) correlates with increased breast cancer risk. We previously demonstrated that NBCn1 expression...

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Veröffentlicht in:	Biochemical journal Jg. 473; H. 21; S. 4027
Hauptverfasser:	Gorbatenko, Andrej, Olesen, Christina W, Loebl, Nathalie, Sigurdsson, Haraldur H, Bianchi, Carolina, Pedraz-Cuesta, Elena, Christiansen, Jan, Pedersen, Stine Falsig
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.11.2016
Schlagworte:	3' Untranslated Regions - genetics Blotting, Western Breast Neoplasms - genetics Breast Neoplasms - metabolism Electrophoretic Mobility Shift Assay Female Fluorescent Antibody Technique Humans MCF-7 Cells Real-Time Polymerase Chain Reaction Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism RNA Stability - genetics RNA Stability - physiology Sodium-Bicarbonate Symporters - genetics Sodium-Bicarbonate Symporters - metabolism posttranscriptional regulation sodium bicarbonate transport microRNA HuR HER2 pH regulation
ISSN:	1470-8728, 1470-8728
Online-Zugang:	Weitere Angaben
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