Association between CD8+ T‐cell subsets and cardiovascular disease
Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and car...
Uloženo v:
| Vydáno v: | Journal of internal medicine Ročník 274; číslo 1; s. 41 - 51 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
01.07.2013
|
| Témata: | |
| ISSN: | 0954-6820, 1365-2796, 1365-2796 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Background
The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and carotid disease as well as development of cardiovascular disease events.
Methods
The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991–1994 baseline investigation and stored at −140 °C, were thawed and the different CD8+ T‐cell populations analysed by flow cytometry. Baseline carotid intima–media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers.
Results
Subjects with a high fraction of CD8+ T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8+ T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8+CD25+ T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8+CD56−IFN‐γ+ T‐cell fraction and the degree of stenosis (r = −0.18, P < 0.005). The association between CD8+CD56−IFN‐γ+ T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors.
Conclusion
This study provides prospective clinical evidence for a role of CD8+ T cells in cardiovascular disease and suggests the existence of CD8+ T‐cell subsets with different pathological functions. |
|---|---|
| AbstractList | Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and carotid disease as well as development of cardiovascular disease events. Methods The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991–1994 baseline investigation and stored at −140 °C, were thawed and the different CD8+ T-cell populations analysed by flow cytometry. Baseline carotid intima–media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. Results Subjects with a high fraction of CD8+ T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8+ T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8+CD25+ T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8+CD56−IFN-γ+ T-cell fraction and the degree of stenosis (r = −0.18, P < 0.005). The association between CD8+CD56−IFN-γ+ T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. Conclusion This study provides prospective clinical evidence for a role of CD8+ T cells in cardiovascular disease and suggests the existence of CD8+ T-cell subsets with different pathological functions. OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. RESULTS: Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leukocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r=0.11, P<0.01), and between the CD8(+) CD56(-) IFN-γ(+) T cell fraction and the degree of stenosis (r=-0.18, P<0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. CONCLUSION: The present study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T cell subsets with different pathological functions. © 2013 The Association for the Publication of the Journal of Internal Medicine. The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140 °C, were thawed and the different CD8(+) T-cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8(+) CD56(-) IFN-γ(+) T-cell fraction and the degree of stenosis (r = -0.18, P < 0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. This study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T-cell subsets with different pathological functions. Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and carotid disease as well as development of cardiovascular disease events. Methods The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991–1994 baseline investigation and stored at −140 °C, were thawed and the different CD8+ T‐cell populations analysed by flow cytometry. Baseline carotid intima–media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. Results Subjects with a high fraction of CD8+ T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8+ T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8+CD25+ T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8+CD56−IFN‐γ+ T‐cell fraction and the degree of stenosis (r = −0.18, P < 0.005). The association between CD8+CD56−IFN‐γ+ T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. Conclusion This study provides prospective clinical evidence for a role of CD8+ T cells in cardiovascular disease and suggests the existence of CD8+ T‐cell subsets with different pathological functions. The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events.BACKGROUNDThe findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events.The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140 °C, were thawed and the different CD8(+) T-cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers.METHODSThe study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140 °C, were thawed and the different CD8(+) T-cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers.Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8(+) CD56(-) IFN-γ(+) T-cell fraction and the degree of stenosis (r = -0.18, P < 0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors.RESULTSSubjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8(+) CD56(-) IFN-γ(+) T-cell fraction and the degree of stenosis (r = -0.18, P < 0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors.This study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T-cell subsets with different pathological functions.CONCLUSIONThis study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T-cell subsets with different pathological functions. |
| Author | Björkbacka, H. Fredrikson, G. N. Hedblad, B. Nilsson, J. Kolbus, D. Ljungcrantz, I. Andersson, L. |
| Author_xml | – sequence: 1 givenname: D. surname: Kolbus fullname: Kolbus, D. organization: Lund University – sequence: 2 givenname: I. surname: Ljungcrantz fullname: Ljungcrantz, I. organization: Lund University – sequence: 3 givenname: L. surname: Andersson fullname: Andersson, L. organization: Lund University – sequence: 4 givenname: B. surname: Hedblad fullname: Hedblad, B. organization: Lund University – sequence: 5 givenname: G. N. surname: Fredrikson fullname: Fredrikson, G. N. organization: Malmö University – sequence: 6 givenname: H. surname: Björkbacka fullname: Björkbacka, H. organization: Lund University – sequence: 7 givenname: J. surname: Nilsson fullname: Nilsson, J. organization: Lund University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23356723$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4958$$DView record from Swedish Publication Index |
| BookMark | eNp1kc1u1DAQxy1URLeFCw-AckSqUvxt57ja5aOoqJfCdWQnE3CVxCFOuuqNR-AZeRK8u6U3fBlL_mnm7_mdkZMhDkjIa0YvWT7v7mLoLxmnwj4jKya0Krmp9AlZ0UrJUltOT8lZSneUMkE1fUFOuRBKGy5WZLtOKdbBzSEOhcd5hzgUm629KG7__PpdY9cVafEJ51S4oSlqNzUh3rtUL52biiYkdAlfkuet6xK-eqzn5OuH97ebT-X1zcerzfq6HCVTthSNQC5zTOksVV7VDJUx3rTe05bKljdceFOjqXK0VjRV411bceN1i4paJc6JO_ZNOxwXD-MUejc9QHQBxjjNroMJc6Kp_gHdAgkhU12oD79L4CojvLAGlEIHshEOvFYaqNG20kwKrmiecfHfGdvwbQ1x-g69W0BWymb67ZEep_hzwTRDH9J-a27AuCTINoy1lEmZ0TeP6OJ7bJ4a_3ORAXYEdqHDh6d3RmFvGfaW4WAZPt9cfTncxF-CDJ0E |
| ContentType | Journal Article |
| Copyright | 2013 The Association for the Publication of the Journal of Internal Medicine 2013 The Association for the Publication of the Journal of Internal Medicine. |
| Copyright_xml | – notice: 2013 The Association for the Publication of the Journal of Internal Medicine – notice: 2013 The Association for the Publication of the Journal of Internal Medicine. |
| CorporateAuthor | Kardiovaskulär forskning - epidemiologi Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) EpiHealth: Epidemiology for Health EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Strategic research areas (SRA) Medicinska fakulteten Kardiovaskulär forskning - immunitet och ateroskleros Cardiovascular Research - Immunity and Atherosclerosis Cardiovascular Research - Epidemiology Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Kardiovaskulär forskning - epidemiologi – name: Strategiska forskningsområden (SFO) – name: Cardiovascular Research - Immunity and Atherosclerosis – name: Kardiovaskulär forskning - immunitet och ateroskleros – name: EpiHealth: Epidemiology for Health – name: Institutionen för kliniska vetenskaper, Malmö – name: Strategic research areas (SRA) – name: Lunds universitet – name: Profilområden och andra starka forskningsmiljöer – name: Lund University – name: EXODIAB: Excellence of Diabetes Research in Sweden – name: Profile areas and other strong research environments – name: Cardiovascular Research - Epidemiology – name: Department of Clinical Sciences, Malmö |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 ADTPV AOWAS D95 |
| DOI | 10.1111/joim.12038 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic SwePub SwePub Articles SWEPUB Lunds universitet |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1365-2796 |
| EndPage | 51 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_a973b387_55ea_4d3a_b656_076896143250 oai_DiVA_org_mau_4958 23356723 JOIM12038 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: VINNOVA – fundername: Crafoord Foundation – fundername: Swedish Foundation for Strategic Research – fundername: Swedish Heart‐Lung Foundation – fundername: Malmö University Hospital Foundation – fundername: Lundström Foundation – fundername: Swedish Research Council – fundername: Söderberg Foundation – fundername: Albert Påhlsson Foundation |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 29K 2WC 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEGXH AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFEBI AFFNX AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AI. AIACR AIAGR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F D-I DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO E3Z EBS EJD EMOBN EX3 F00 F01 F04 F5P FEDTE FIJ FUBAC G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SJN SUPJJ TEORI TR2 UB1 V8K V9Y VH1 VVN W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WVDHM WXI WXSBR X7M XG1 YFH YOC YUY ZCG ZGI ZXP ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM 7X8 ADTPV AOWAS D95 |
| ID | FETCH-LOGICAL-p4158-3d3e240384a805b5c1e577b7fbb0f04f2d23b7ce79723f3d9dbaf927b6fe50853 |
| IEDL.DBID | WIN |
| ISICitedReferencesCount | 54 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000320279000003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0954-6820 1365-2796 |
| IngestDate | Sat Oct 25 06:25:13 EDT 2025 Tue Nov 04 16:51:20 EST 2025 Fri Jul 11 11:37:40 EDT 2025 Mon Jul 21 06:03:27 EDT 2025 Tue Nov 11 03:09:31 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2013 The Association for the Publication of the Journal of Internal Medicine. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p4158-3d3e240384a805b5c1e577b7fbb0f04f2d23b7ce79723f3d9dbaf927b6fe50853 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12038 |
| PMID | 23356723 |
| PQID | 1367880144 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_a973b387_55ea_4d3a_b656_076896143250 swepub_primary_oai_DiVA_org_mau_4958 proquest_miscellaneous_1367880144 pubmed_primary_23356723 wiley_primary_10_1111_joim_12038_JOIM12038 |
| PublicationCentury | 2000 |
| PublicationDate | July 2013 |
| PublicationDateYYYYMMDD | 2013-07-01 |
| PublicationDate_xml | – month: 07 year: 2013 text: July 2013 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of internal medicine |
| PublicationTitleAlternate | J Intern Med |
| PublicationYear | 2013 |
| References | 2010; 11 2004; 165 2005; 174 2010; 209 2006; 12 2008; 39 2000; 152 2011; 12 1999; 85 2003; 19 2012; 224 2011; 6 1996; 16 2008; 263 2011; 134 2012; 32 2003; 254 2001; 103 1996; 149 2007; 38 2000; 17 1997; 96 2000; 97 2006; 26 2002; 420 2008; 43 2005; 2 2012; 7 2003; 102 2012; 5 2001; 30 2009; 15 1993; 233 2003; 362 1985; 254 2001; 32 |
| References_xml | – volume: 32 start-page: 2000 year: 2012 end-page: 4 article-title: Low levels of circulating CD4 FoxP3 T cells are associated with an increased risk for development of Myocardial Infarction but not for stroke publication-title: Arterioscler Thromb Vasc Biol – volume: 12 start-page: 1075 year: 2006 end-page: 80 article-title: Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis publication-title: Nat Med – volume: 209 start-page: 545 year: 2010 end-page: 50 article-title: Leukocyte count is associated with incidence of coronary events, but not with stroke: a prospective cohort study publication-title: Atherosclerosis – volume: 2 start-page: 639 year: 2005 end-page: 46 article-title: Immunomodulation of atherosclerosis with a vaccine publication-title: Nat Clin Pract Cardiovasc Med – volume: 11 start-page: 58 year: 2010 article-title: CD8 T cell activation predominate early immune responses to hypercholesterolemia in Apoe(/) mice publication-title: BMC Immunol – volume: 254 start-page: 472 year: 2003 end-page: 8 article-title: Expansion of peripheral CD8 T cells in patients with coronary artery disease: relation to cytomegalovirus infection publication-title: J Intern Med – volume: 174 start-page: 6509 year: 2005 end-page: 17 article-title: Human 60‐kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques publication-title: J Immunol – volume: 39 start-page: 1756 year: 2008 end-page: 62 article-title: Requirements for CD8 T‐cell migration into the human arterial wall publication-title: Hum Pathol – volume: 16 start-page: 843 year: 1996 end-page: 50 article-title: On quantifying plaque size and intima‐media thickness in carotid and femoral arteries. Comments on results from a prospective ultrasound study in patients with familial hypercholesterolemia publication-title: Arterioscler Thromb Vasc Biol – volume: 32 start-page: 1966 year: 2001 end-page: 72 article-title: Increased CD8(+) T cells associated with Chlamydia pneumoniae in symptomatic carotid plaque publication-title: Stroke – volume: 263 start-page: 464 year: 2008 end-page: 78 article-title: Autoimmunity in atherosclerosis: a protective response losing control? publication-title: J Intern Med – volume: 85 start-page: e17 year: 1999 end-page: 24 article-title: Protective role of interleukin‐10 in atherosclerosis publication-title: Circ Res – volume: 149 start-page: 359 year: 1996 end-page: 66 article-title: Evidence for a local immune response in atherosclerosis. CD4 T cells infiltrate lesions of apolipoprotein‐E‐deficient mice publication-title: Am J Pathol – volume: 134 start-page: 17 year: 2011 end-page: 32 article-title: CD8 CD28‐ and CD8 CD57 T cells and their role in health and disease publication-title: Immunology – volume: 15 start-page: 914 year: 2009 end-page: 20 article-title: CD8 effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity publication-title: Nat Med – volume: 233 start-page: 43 year: 1993 end-page: 51 article-title: The Malmö diet cancer study: design and feasibility publication-title: J Intern Med – volume: 6 start-page: e20214 year: 2011 article-title: Enhanced neointima formation following arterial injury in immune deficient Rag‐1−/− mice is attenuated by adoptive transfer of CD8 T cells publication-title: PLoS ONE – volume: 7 start-page: e33932 year: 2012 article-title: TAP1‐deficiency does not alter atherosclerosis development in Apoe(−/−) mice publication-title: PLoS ONE – volume: 224 start-page: 515 year: 2012 end-page: 20 article-title: Persistent accumulation of interferon‐gamma‐producing CD8(+)CD56(+) T cells in blood from patients with coronary artery disease publication-title: Atherosclerosis – volume: 5 start-page: 122 year: 2012 end-page: 31 article-title: Elevated CD14 CD16‐ monocytes predict cardiovascular events publication-title: Circ Cardiovasc Genet – volume: 102 start-page: 4107 year: 2003 end-page: 14 article-title: Human CD8 CD25 thymocytes share phenotypic and functional features with CD4 CD25 regulatory thymocytes publication-title: Blood – volume: 96 start-page: 1102 year: 1997 end-page: 8 article-title: Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study publication-title: Circulation – volume: 152 start-page: 334 year: 2000 end-page: 46 article-title: Occupational status, educational level, and the prevalence of carotid atherosclerosis in a general population sample of middle‐aged Swedish men and women: results from the Malmo diet and cancer study publication-title: Am J Epidemiol – volume: 32 start-page: 533 year: 2012 end-page: 9 article-title: Incidence of coronary events and case fatality rate in relation to blood lymphocyte and neutrophil counts publication-title: Arterioscler Thromb Vasc Biol – volume: 254 start-page: 1932 year: 1985 end-page: 7 article-title: Prognostic importance of the white blood cell count for coronary, cancer, and all‐cause mortality publication-title: J Am Med Assoc – volume: 97 start-page: 12752 year: 2000 end-page: 7 article-title: Linking immune‐mediated arterial inflammation and cholesterol‐induced atherosclerosis in a transgenic mouse model publication-title: Proc Natl Acad Sci USA – volume: 19 start-page: 71 year: 2003 end-page: 82 article-title: Blood monocytes consist of two principal subsets with distinct migratory properties publication-title: Immunity – volume: 165 start-page: 2013 year: 2004 end-page: 8 article-title: Deleting TCR alpha beta+ or CD4 T lymphocytes leads to opposite effects on site‐specific atherosclerosis in female apolipoprotein E‐deficient mice publication-title: Am J Pathol – volume: 43 start-page: 229 year: 2008 end-page: 37 article-title: T‐cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T‐cell receptor repertoire publication-title: Exp Gerontol – volume: 103 start-page: 1721 year: 2001 end-page: 6 article-title: Low dose metropolol CR/XL and fluvastatin slow progression of carotid intima‐media thickness (IMT). Main results from the beta‐blocker cholesterol asymptomatic plaque study (BCAPS) publication-title: Circulation – volume: 26 start-page: 2421 year: 2006 end-page: 32 article-title: T cells in atherogenesis: for better or for worse? publication-title: Arterioscler Thromb Vasc Biol – volume: 30 start-page: S30 issue: Suppl 1 year: 2001 end-page: 4 article-title: A national record linkage to study acute myocardial infarction incidence and case fatality in Sweden publication-title: Int J Epidemiol – volume: 362 start-page: 1971 year: 2003 end-page: 7 article-title: Interaction of antibodies against cytomegalovirus with heat‐shock protein 60 in pathogenesis of atherosclerosis publication-title: Lancet – volume: 7 start-page: e30780 year: 2012 article-title: CD8 T cells mediate the athero‐protective effect of immunization with an ApoB‐100 peptide publication-title: PLoS ONE – volume: 420 start-page: 868 year: 2002 end-page: 74 article-title: Inflammation in atherosclerosis publication-title: Nature – volume: 12 start-page: 204 year: 2011 end-page: 12 article-title: The immune system in atherosclerosis publication-title: Nat Immunol – volume: 38 start-page: 2681 year: 2007 end-page: 5 article-title: Blood pressure in relation to the incidence of cerebral infarction and intracerebral hemorrhage. Hypertensive hemorrhage: debated nomenclature is still relevant publication-title: Stroke – volume: 17 start-page: 299 year: 2000 end-page: 307 article-title: Relation between insulin resistance and carotid intima‐media thickness and stenosis in non‐diabetic subjects. Results from a cross‐sectional study in Malmo, Sweden publication-title: Diabet Med |
| SSID | ssj0013060 |
| Score | 2.3129687 |
| Snippet | Background
The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different... The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells... Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different... OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different... |
| SourceID | swepub proquest pubmed wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 41 |
| SubjectTerms | Aged Biomarkers - blood Cardiology and Cardiovascular Disease Cardiovascular Diseases - immunology Carotid Intima-Media Thickness Carotid Stenosis - diagnostic imaging Carotid Stenosis - epidemiology Carotid Stenosis - immunology Carotid Stenosis - physiopathology CD56 Antigen - analysis CD8+ T cell CD8-Positive T-Lymphocytes - immunology Clinical Medicine Cohort Studies Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - immunology Coronary Artery Disease - physiopathology cytokines Cytokines - secretion Female Flow Cytometry Humans Incidence Interleukin-2 Receptor alpha Subunit - analysis Kaplan-Meier Estimate Kardiologi och kardiovaskulära sjukdomar Klinisk medicin Leukocytes - immunology Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged myocardial infarction Odds Ratio Predictive Value of Tests Proportional Hazards Models Prospective Studies Registries Risk Assessment Risk Factors Severity of Illness Index stroke Stroke - diagnostic imaging Stroke - epidemiology Stroke - immunology Stroke - physiopathology Sweden - epidemiology |
| Title | Association between CD8+ T‐cell subsets and cardiovascular disease |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjoim.12038 https://www.ncbi.nlm.nih.gov/pubmed/23356723 https://www.proquest.com/docview/1367880144 https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4958 |
| Volume | 274 |
| WOSCitedRecordID | wos000320279000003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1365-2796 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0013060 issn: 1365-2796 databaseCode: WIN dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1365-2796 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0013060 issn: 1365-2796 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1RT9swED4xQBMvG4PBwljlSTwNZUpip3YkXhClGtPoEIJR8XKyE3urNNKqaffMT-A38kuwnZAViZdpb5FiJ5bPd_7Od_4OYI8VWhgWs1DxRIfMIg6XBJCHMrMWM2Zc50b5YhN8MBDDYXa2BAePd2Fqfoj2wM1phrfXTsGlqhaVfDy6-RwnEXU3fWPmtfLqZPA3hBD5K8IWQrCwa_e5hpvUp_G0XZ_DlS1p6FO86jec_uv_G-o6vGqAJjmsV8YbWNLlBrw8bULpm9BbEAxpsrXIUU_sk4v72zt3nk8qa1T0rCKyLEj-JG-VNHGdt3DZP744-hI2JRXCid2pRUgLqh0Dn2BSRKlK81innCtulIpMxExSJFTxXHNXjMzQIiuUNFnCVddoC-VSugXL5bjU74BQIWWSZ0paJ4hJLmTXpFxTYa0E19KYAD4-Ti3aJevGLUs9nlfoWOKEY61hAWzXc46TmlsDE0rTrv13AHu1ENo3jge7N_pxiOPpT7yRc7SunQjg-plmteeCDV3SL_w9x0rjZOEcFGXGqaKCY5pqiaygEpWFtugCk5mFLNRCwwA-eam2324dJitP9PLEr99PTv3Tzr80fg9riS-r4dJ-d2F5Np3rD7Ca_5mNqmkHXvCh6MBK77x_-a3jV_UDM_r51w |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbxMxEB5BioAL78KWl5F6Ai3arO3Ye6waohaSgFCKKi4je9cukegmyiac-Qn8Rn5Jba9ZUqkXxG2l9T7kGY-_efgbgH1WGWlZn6Va5CZlDnH4IoAyVYWzmH0mTGl1aDYhplN5elp8irU5_ixMyw_RBdz8ygj22i9wH5DeXuWL-fnbfp5ReR12mNMj3oOd4efRyfhvGiELx4QdjGDpwO11kZ80lPJ0T1-FLTvi0MuYNWw6o7v_-bv34E5Em-SgVY_7cM3UD-DmJObTH8JwSzoklmyRw6F8Q2a_f_7yQX3SOMti1g1RdUXKS8WrJCZ3HsHJ6N3s8CiNfRXSpduuZUorajwNn2RKZlzzsm-4EFpYrTObMZtXOdWiNMJ3JLO0KiqtbJELPbDG4TlOd6FXL2rzBAiVSuVloZXzhJgSUg0sF4ZKZyqEUdYm8OrP3KLTW__fqjaLTYOeKk566hqWwON20nHZEmxgTikfuG8nsN9KobvjybCH8y8HuFid4bnaoPPvZAJfrxjWui8YOZO-4fcNNgaXW8FQVIWgmkqBnBuFrKIKtcO36LOThcMt1OHDBF4HsXbv7rwmJ08M8sT3H48n4WrvXwa_hFtHs8kYx8fTD0_hdh76bPg64GfQW6825jncKH-s583qRVTrCwdU_Js |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BiyouvB-hPIzUEygoG9uxc6waVhTapUItqriM7MRuV6LZ1WaXMz-B38gvqe2YsJV6QdwixXnI8_A3nvE3ADusMdKyEUu1yE3KHOLwRQB1qkrnMUdMmNrq0GxCTCby9LQ8irU5_ixMzw8xbLh5ywj-2hu4mTd23cpn04t3ozyj8iZsMl4Wzi43qy_jk4O_aYQsHBN2MIKlhVvrIj9pKOUZnr4OWw7EoVcxa1h0xnf_83fvwZ2INslurx734YZpH8DWYcynP4RqTToklmyRvUq-Jce_f_7ym_qkc57FLDui2obUV4pXSUzuPIKT8fvjvQ9p7KuQzt1yLVPaUONp-CRTMuOa1yPDhdDCap3ZjNm8yakWtRG-I5mlTdloZctc6MIah-c4fQwb7aw1T4FQqVRel1q5SIgpIVVhuTBUOlchjLI2gdd_5had3vr_Vq2ZrTr0VHHSU9ewBJ70k47znmADc0p54b6dwE4vheGOJ8Oupl93cbY4wwu1QhffyQS-XTOsD18wciad4_cVdgbna5uhqEpBNZUCOTcKWUMVaodv0WcnnTox6vBhAm-CWId3D1GTkycGeeLHz_uH4erZvwx-BVtH1RgP9ieftuF2Htps-DLg57CxXKzMC7hV_1hOu8XLqNWXmJL8Fg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+between+CD8%28%2B%29+T+cell+subsets+and+cardiovascular+disease&rft.jtitle=Journal+of+internal+medicine&rft.au=Kolbus%2C+Daniel&rft.au=Ljungcrantz%2C+Irena&rft.au=Andersson%2C+Linda&rft.au=Hedblad%2C+Bo&rft.date=2013-07-01&rft.issn=1365-2796&rft.volume=274&rft.issue=1&rft.spage=41&rft_id=info:doi/10.1111%2Fjoim.12038&rft.externalDocID=oai_portal_research_lu_se_publications_a973b387_55ea_4d3a_b656_076896143250 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0954-6820&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0954-6820&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0954-6820&client=summon |