Association between CD8+ T‐cell subsets and cardiovascular disease

Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and car...

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Bibliographic Details
Published in:Journal of internal medicine Vol. 274; no. 1; pp. 41 - 51
Main Authors: Kolbus, D., Ljungcrantz, I., Andersson, L., Hedblad, B., Fredrikson, G. N., Björkbacka, H., Nilsson, J.
Format: Journal Article
Language:English
Published: England 01.07.2013
Subjects:
Aged
Biomarkers - blood
Cardiology and Cardiovascular Disease
Cardiovascular Diseases - immunology
Carotid Intima-Media Thickness
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - epidemiology
Carotid Stenosis - immunology
Carotid Stenosis - physiopathology
CD56 Antigen - analysis
CD8+ T cell
CD8-Positive T-Lymphocytes - immunology
Clinical Medicine
Cohort Studies
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - immunology
Coronary Artery Disease - physiopathology
cytokines
Cytokines - secretion
Female
Flow Cytometry
Humans
Incidence
Interleukin-2 Receptor alpha Subunit - analysis
Kaplan-Meier Estimate
Kardiologi och kardiovaskulära sjukdomar
Klinisk medicin
Leukocytes - immunology
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
myocardial infarction
Odds Ratio
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Registries
Risk Assessment
Risk Factors
Severity of Illness Index
stroke
Stroke - diagnostic imaging
Stroke - epidemiology
Stroke - immunology
Stroke - physiopathology
Sweden - epidemiology
ISSN:0954-6820, 1365-2796, 1365-2796
Online Access:Get full text
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Summary:Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and carotid disease as well as development of cardiovascular disease events. Methods The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991–1994 baseline investigation and stored at −140 °C, were thawed and the different CD8+ T‐cell populations analysed by flow cytometry. Baseline carotid intima–media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. Results Subjects with a high fraction of CD8+ T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8+ T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8+CD25+ T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8+CD56−IFN‐γ+ T‐cell fraction and the degree of stenosis (r = −0.18, P < 0.005). The association between CD8+CD56−IFN‐γ+ T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. Conclusion This study provides prospective clinical evidence for a role of CD8+ T cells in cardiovascular disease and suggests the existence of CD8+ T‐cell subsets with different pathological functions.
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ISSN:0954-6820
1365-2796
1365-2796
DOI:10.1111/joim.12038