The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

The E3 ubiquitin ligase RNF8 (RING finger protein 8) is a pivotal enzyme for DNA repair. However, RNF8 hyper‐accumulation is tumour‐promoting and positively correlates with genome instability, cancer cell invasion, metastasis and poor patient prognosis. Very little is known about the mechanisms regu...

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Veröffentlicht in:	The EMBO journal Jg. 38; H. 21; S. e102361 - n/a
Hauptverfasser:	Singh, Abhay Narayan, Oehler, Judith, Torrecilla, Ignacio, Kilgas, Susan, Li, Shudong, Vaz, Bruno, Guérillon, Claire, Fielden, John, Hernandez‐Carralero, Esperanza, Cabrera, Elisa, Tullis, Iain DC, Meerang, Mayura, Barber, Paul R, Freire, Raimundo, Parsons, Jason, Vojnovic, Borivoj, Kiltie, Anne E, Mailand, Niels, Ramadan, Kristijan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 04.10.2019 Springer Nature B.V John Wiley and Sons Inc
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Ataxin Ataxin 3 Ataxin-3 - genetics Ataxin-3 - metabolism BRCA2 protein Breast cancer Cancer Cell Survival Chromatin Chromatin - genetics Damage Deactivation Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA double‐strand break repair DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E3 ubiquitin ligase RNF8 EMBO13 EMBO31 genome stability Genomes Genomic Instability Genotoxicity HEK293 Cells HeLa Cells Homeostasis Homologous recombination Homology Humans Inactivation Ionizing radiation Medical prognosis Metastases Non-homologous end joining Nuclear Proteins - genetics Nuclear Proteins - metabolism p97/VCP ATPase Physiology Proteasome Endopeptidase Complex - metabolism Proteasomes Proteolysis Recruitment Repair Signal Transduction Tumors Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination genome stability DNA double‐strand break repair Ataxin 3 p97/VCP ATPase E3 ubiquitin ligase RNF8 DNA double-strand break repair
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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