HIV‐1 Tat C modulates NOX2 and NOX4 expressions through miR‐17 in a human microglial cell line

HIV‐1 invades CNS in the early course of infection, which can lead to the cascade of neuroinflammation. NADPH oxidases (NOXs) are the major producers of reactive oxygen species (ROS), which play important roles during pathogenic insults. The molecular mechanism of ROS generation via microRNA‐mediate...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 131; no. 6; pp. 803 - 815
Main Authors:	Jadhav, Vaishnavi Sunil, Krause, Karl‐Heinz, Singh, Sunit K.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.12.2014
Subjects:	Cell Line Cells, Cultured Cellular biology CNS Cytokines HIV HIV-1 - isolation & purification HIV-1 - metabolism HIV‐1 Tat Human immunodeficiency virus Human immunodeficiency virus 1 Humans Membrane Glycoproteins - metabolism microglia Microglia - metabolism microRNA MicroRNAs - metabolism Mutagenesis, Site-Directed - methods NADPH Oxidase 2 NADPH Oxidase 4 NADPH oxidases NADPH Oxidases - metabolism Neurological disorders Proteins Reactive Oxygen Species - metabolism ROS tat Gene Products, Human Immunodeficiency Virus - isolation & purification tat Gene Products, Human Immunodeficiency Virus - metabolism CNS HIV-1 Tat microRNA NADPH oxidases microglia ROS
ISSN:	0022-3042, 1471-4159, 1471-4159
Online Access:	Get full text
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