Surveillance of Influenza in Indonesia, 2003–2007

Background  Longitudinal data are limited about the circulating strains of influenza viruses and their public health impact in Indonesia. We conducted influenza surveillance among outpatients and hospitalized patients with influenza‐like illness (ILI) across the Indonesian archipelago from 2003 thro...

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Vydané v:Influenza and other respiratory viruses Ročník 7; číslo 3; s. 312 - 320
Hlavní autori: Kosasih, Herman,  , Roselinda,  , Nurhayati, Klimov, Alexander, Xiyan, Xu, Lindstrom, Stephen, Mahoney, Frank, Beckett, Charmagne, Burgess, Timothy H., Blair, Patrick J., Uyeki, Timothy M., Sedyaningsih, Endang R.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford, UK Blackwell Publishing Ltd 01.05.2013
Predmet:
Adolescent
Adult
Aged
Child
Child, Preschool
Female
Humans
Indonesia
Indonesia - epidemiology
Infant
influenza
Influenza A virus
Influenza A virus - classification
Influenza A virus - genetics
Influenza A virus - isolation & purification
Influenza B virus - classification
Influenza B virus - genetics
Influenza B virus - isolation & purification
Influenza, Human - epidemiology
Influenza, Human - virology
Male
Middle Aged
Original
Part 1
Retrospective Studies
Seasons
Sentinel Surveillance
surveillance
Young Adult
Indonesia
Asia
ISSN:1750-2640, 1750-2659, 1750-2659
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Shrnutí:Background  Longitudinal data are limited about the circulating strains of influenza viruses and their public health impact in Indonesia. We conducted influenza surveillance among outpatients and hospitalized patients with influenza‐like illness (ILI) across the Indonesian archipelago from 2003 through 2007. Methodology  Demographic, clinical data, and respiratory specimens were collected for 4236 ILI patients tested for influenza virus infection by RT‐PCR and viral culture. Principal Findings  Influenza A and B viruses co‐circulated year‐round with seasonal peaks in influenza A virus activity during the rainy season (December–January). During 2003–2007, influenza viruses were identified in 20·1% (4236/21 030) of ILI patients, including 20·1% (4015/20 012) of outpatients, and 21·7% (221/1018) of inpatients. One H5N1 case was identified retrospectively in an outpatient with ILI. Antigenic drift in circulating influenza A and B virus strains was detected during the surveillance period in Indonesia. In a few instances, antigenically drifted viruses similar to the World Health Organization (WHO) vaccine strains were detected earlier than the date of their designation by WHO. Conclusions  Influenza A and B virus infections are an important cause of influenza‐like illness among outpatients and hospitalized patients in Indonesia. While year‐round circulation of influenza viruses occurs, prevention and control strategies should be focused upon the seasonal peak during rainy season months. Ongoing virologic surveillance and influenza disease burden studies in Indonesia are important priorities to better understand the public health impact of influenza in South‐East Asia and the implications of influenza viral evolution and global spread.
Bibliografia:ObjectType-Article-2
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ISSN:1750-2640
1750-2659
1750-2659
DOI:10.1111/j.1750-2659.2012.00403.x