Long non-coding RNA NEAT1-centric gene regulation

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA that is widely expressed in a variety of mammalian cell types. An increasing number of studies have demonstrated that NEAT1 plays key roles in various biological and pathological processes; therefore, it is important to under...

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Vydané v:Cellular and molecular life sciences : CMLS Ročník 77; číslo 19; s. 3769 - 3779
Hlavní autori: Wang, Ziqiang, Li, Kun, Huang, Weiren
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cham Springer International Publishing 01.10.2020
Springer Nature B.V
Predmet:
Alzheimer's disease
Biochemistry
Biological activity
Biomedical and Life Sciences
Biomedicine
Cell Biology
Epithelial-Mesenchymal Transition
Gene expression
Gene Expression Regulation
Gene regulation
Genes
Herpes simplex
Humans
Life Sciences
mammals
MicroRNAs - metabolism
Molecular modelling
Neurodegenerative diseases
Non-coding RNA
Review
Ribonucleic acid
RNA
RNA 3' End Processing
RNA Splicing
RNA Stability
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA-Binding Proteins - metabolism
signal transduction
transactivators
transcription (genetics)
Transcription Factors - metabolism
RNA stabilization
Transcription
NEAT1
RBPs
Gene regulation
ISSN:1420-682X, 1420-9071, 1420-9071
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Popis
Shrnutí:Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA that is widely expressed in a variety of mammalian cell types. An increasing number of studies have demonstrated that NEAT1 plays key roles in various biological and pathological processes; therefore, it is important to understand how its expression is regulated and how it regulates the expression of its target genes. Recently, we found that NEAT1 expression could be regulated by signal transducer and activator of transcription 3 and that altered NEAT1 expression epigenetically regulates downstream gene transcription during herpes simplex virus-1 infection and Alzheimer’s disease, suggesting that NEAT1 acts as an important sensor and effector during stress and disease development. In this review, we summarize and discuss the molecules and regulatory patterns that control NEAT1 gene expression and the molecular mechanism via which NEAT1 regulates the expression of its target genes, providing novel insights into the central role of NEAT1 in gene regulation.
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ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-020-03503-0