The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis
Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar , a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional...
Saved in:
| Published in: | The EMBO journal Vol. 37; no. 10 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
15.05.2018
Springer Nature B.V John Wiley and Sons Inc |
| Subjects: | |
| ISSN: | 0261-4189, 1460-2075, 1460-2075 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their
in vivo
roles and mechanisms of action remain poorly understood.
Paupar
, a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome‐wide manner. We show here that the
Paupar
lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation.
Paupar
promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing
Paupar
, KAP1 and the PAX6 transcription factor.
Paupar
‐KAP1 genome‐wide co‐occupancy reveals a fourfold enrichment of overlap between
Paupar
and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both
Paupar
and
Kap1
loss‐of‐function
in vivo
disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the
trans
‐acting modes of lncRNA‐mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify
Paupar
and
Kap1
as regulators of neurogenesis
in vivo
.
Synopsis
The formation of an RNP complex containing a long non‐coding RNA (lncRNA), a chromatin regulator and transcription factor illustrates how a single nuclear lncRNA can regulate transcription of multiple target genes in
trans
.
The CNS‐expressed lncRNA
Paupar
interacts with the TRIM28/TIF1/KAP1 chromatin regulatory protein.
Paupar
acts in
trans
to promote KAP1 chromatin occupancy and H3K9me3 deposition at a subset of bound target sites.
Paupar
regulation in
trans
requires the formation of a ribonucleoprotein complex containing
Paupar
, KAP1 and non‐KRAB‐ZNF transcription factors such as PAX6.
Paupar
and KAP1 function as regulators of olfactory bulb neurogenesis
in vivo
.
Graphical Abstract
Complex formation between a long non‐coding RNA (lncRNA), a chromatin regulator and transcription factor illustrates how nuclear lncRNAs can regulate transcription in
trans
. |
|---|---|
| AbstractList | Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their
in vivo
roles and mechanisms of action remain poorly understood.
Paupar
, a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome‐wide manner. We show here that the
Paupar
lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation.
Paupar
promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing
Paupar
, KAP1 and the PAX6 transcription factor.
Paupar
‐KAP1 genome‐wide co‐occupancy reveals a fourfold enrichment of overlap between
Paupar
and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both
Paupar
and
Kap1
loss‐of‐function
in vivo
disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the
trans
‐acting modes of lncRNA‐mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify
Paupar
and
Kap1
as regulators of neurogenesis
in vivo
.
Synopsis
The formation of an RNP complex containing a long non‐coding RNA (lncRNA), a chromatin regulator and transcription factor illustrates how a single nuclear lncRNA can regulate transcription of multiple target genes in
trans
.
The CNS‐expressed lncRNA
Paupar
interacts with the TRIM28/TIF1/KAP1 chromatin regulatory protein.
Paupar
acts in
trans
to promote KAP1 chromatin occupancy and H3K9me3 deposition at a subset of bound target sites.
Paupar
regulation in
trans
requires the formation of a ribonucleoprotein complex containing
Paupar
, KAP1 and non‐KRAB‐ZNF transcription factors such as PAX6.
Paupar
and KAP1 function as regulators of olfactory bulb neurogenesis
in vivo
.
Graphical Abstract
Complex formation between a long non‐coding RNA (lncRNA), a chromatin regulator and transcription factor illustrates how nuclear lncRNAs can regulate transcription in
trans
. Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome‐wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation. Paupar promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing Paupar, KAP1 and the PAX6 transcription factor. Paupar‐KAP1 genome‐wide co‐occupancy reveals a fourfold enrichment of overlap between Paupar and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both Paupar and Kap1 loss‐of‐function in vivo disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the trans‐acting modes of lncRNA‐mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify Paupar and Kap1 as regulators of neurogenesis in vivo. Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome‐wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation. Paupar promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing Paupar, KAP1 and the PAX6 transcription factor. Paupar‐KAP1 genome‐wide co‐occupancy reveals a fourfold enrichment of overlap between Paupar and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both Paupar and Kap1 loss‐of‐function in vivo disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the trans‐acting modes of lncRNA‐mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify Paupar and Kap1 as regulators of neurogenesis in vivo. Synopsis The formation of an RNP complex containing a long non‐coding RNA (lncRNA), a chromatin regulator and transcription factor illustrates how a single nuclear lncRNA can regulate transcription of multiple target genes in trans. The CNS‐expressed lncRNA Paupar interacts with the TRIM28/TIF1/KAP1 chromatin regulatory protein. Paupar acts in trans to promote KAP1 chromatin occupancy and H3K9me3 deposition at a subset of bound target sites. Paupar regulation in trans requires the formation of a ribonucleoprotein complex containing Paupar, KAP1 and non‐KRAB‐ZNF transcription factors such as PAX6. Paupar and KAP1 function as regulators of olfactory bulb neurogenesis in vivo. Complex formation between a long non‐coding RNA (lncRNA), a chromatin regulator and transcription factor illustrates how nuclear lncRNAs can regulate transcription in trans. Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome‐wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation. Paupar promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing Paupar, KAP1 and the PAX6 transcription factor. Paupar‐KAP1 genome‐wide co‐occupancy reveals a fourfold enrichment of overlap between Paupar and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both Paupar and Kap1 loss‐of‐function in vivo disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the trans‐acting modes of lncRNA‐mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify Paupar and Kap1 as regulators of neurogenesis in vivo. Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their roles and mechanisms of action remain poorly understood. , a CNS-expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome-wide manner. We show here that the lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation. promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing , KAP1 and the PAX6 transcription factor. -KAP1 genome-wide co-occupancy reveals a fourfold enrichment of overlap between and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both and loss-of-function disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the -acting modes of lncRNA-mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify and as regulators of neurogenesis . Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS-expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome-wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation. Paupar promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing Paupar, KAP1 and the PAX6 transcription factor. Paupar-KAP1 genome-wide co-occupancy reveals a fourfold enrichment of overlap between Paupar and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both Paupar and Kap1 loss-of-function in vivo disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the trans-acting modes of lncRNA-mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify Paupar and Kap1 as regulators of neurogenesis in vivo.Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar, a CNS-expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional regulatory elements in a genome-wide manner. We show here that the Paupar lncRNA directly binds KAP1, an essential epigenetic regulatory protein, and thereby regulates the expression of shared target genes important for proliferation and neuronal differentiation. Paupar promotes KAP1 chromatin occupancy and H3K9me3 deposition at a subset of distal targets, through the formation of a ribonucleoprotein complex containing Paupar, KAP1 and the PAX6 transcription factor. Paupar-KAP1 genome-wide co-occupancy reveals a fourfold enrichment of overlap between Paupar and KAP1 bound sequences, the majority of which also appear to associate with PAX6. Furthermore, both Paupar and Kap1 loss-of-function in vivo disrupt olfactory bulb neurogenesis. These observations provide important conceptual insights into the trans-acting modes of lncRNA-mediated epigenetic regulation and the mechanisms of KAP1 genomic recruitment, and identify Paupar and Kap1 as regulators of neurogenesis in vivo. |
| Author | Pavlaki, Ioanna Woodcock, Dan J Alammari, Farah Szele, Francis G Sirey, Tamara Ponting, Chris P Vance, Keith W Sun, Bin Lee, Sheena Clark, Neil |
| AuthorAffiliation | 4 Warwick Systems Biology Centre University of Warwick Coventry UK 2 Department of Physiology, Anatomy and Genetics University of Oxford Oxford UK 3 MRC Human Genetics Unit The Institute of Genetics and Molecular Medicine Western General Hospital University of Edinburgh Edinburgh UK 1 Department of Biology and Biochemistry University of Bath Bath UK |
| AuthorAffiliation_xml | – name: 4 Warwick Systems Biology Centre University of Warwick Coventry UK – name: 3 MRC Human Genetics Unit The Institute of Genetics and Molecular Medicine Western General Hospital University of Edinburgh Edinburgh UK – name: 2 Department of Physiology, Anatomy and Genetics University of Oxford Oxford UK – name: 1 Department of Biology and Biochemistry University of Bath Bath UK |
| Author_xml | – sequence: 1 givenname: Ioanna orcidid: 0000-0003-2514-0977 surname: Pavlaki fullname: Pavlaki, Ioanna organization: Department of Biology and Biochemistry, University of Bath – sequence: 2 givenname: Farah surname: Alammari fullname: Alammari, Farah organization: Department of Physiology, Anatomy and Genetics, University of Oxford – sequence: 3 givenname: Bin surname: Sun fullname: Sun, Bin organization: Department of Physiology, Anatomy and Genetics, University of Oxford – sequence: 4 givenname: Neil surname: Clark fullname: Clark, Neil organization: MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh – sequence: 5 givenname: Tamara surname: Sirey fullname: Sirey, Tamara organization: MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh – sequence: 6 givenname: Sheena surname: Lee fullname: Lee, Sheena organization: Department of Physiology, Anatomy and Genetics, University of Oxford – sequence: 7 givenname: Dan J surname: Woodcock fullname: Woodcock, Dan J organization: Warwick Systems Biology Centre, University of Warwick – sequence: 8 givenname: Chris P surname: Ponting fullname: Ponting, Chris P organization: MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh – sequence: 9 givenname: Francis G surname: Szele fullname: Szele, Francis G organization: Department of Physiology, Anatomy and Genetics, University of Oxford – sequence: 10 givenname: Keith W orcidid: 0000-0002-3411-8213 surname: Vance fullname: Vance, Keith W email: k.w.vance@bath.ac.uk organization: Department of Biology and Biochemistry, University of Bath |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29661885$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1u1DAUhS1URKeFNTsUiQ2bFF_H-WOBNFTlt0CFytqynZtMRo6d2gnV7PoIfQSehUfhSXCZMvxIrOyr-52jY58DsmedRUIeAj2CnOXsKQ5qfcQolHXFoL5DFsALmjJa5ntkQVkBKYeq3icHIawppXlVwj2yz-qigKrKF-TyfIWJcbZLovP3q2vtmj4Onz4skzM5j9Ino3eDmzAk75ZnEIkGR7QN2inRq7iSU2_jTdouItI2icduNjIKvn11ppV6cn6TqNmoxOLsXYcWQx_uk7utNAEf3J6H5PPLk_Pj1-npx1dvjpen6ZhRqFPe5JwDaynjQFtslWKlZjQDYFpRlYHOJedYMw0AWpc1NopzqhXXWcVZkx2S51vfcVYDNjrm9tKI0feD9BvhZC_-3th-JTr3ReR1WWVVFg2e3Bp4dzFjmMTQB43GSItuDoLFT-YMWMki-vgfdO1mb-PzIsXLDDgUN9SjPxPtovzqJALPtsBlb3Cz2wMVPysXN5WLXeXi5P2Lt7spiulWHKIuduJ_Z_iPQfYD2yO1iA |
| ContentType | Journal Article |
| Copyright | The Author(s) 2018 2018 The Authors. Published under the terms of the CC BY 4.0 license 2018 The Authors. Published under the terms of the CC BY 4.0 license. 2018 EMBO |
| Copyright_xml | – notice: The Author(s) 2018 – notice: 2018 The Authors. Published under the terms of the CC BY 4.0 license – notice: 2018 The Authors. Published under the terms of the CC BY 4.0 license. – notice: 2018 EMBO |
| DBID | C6C 24P CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 5PM |
| DOI | 10.15252/embj.201798219 |
| DatabaseName | Springer Nature OA Free Journals Wiley Online Library Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
| DatabaseTitleList | Virology and AIDS Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access (LUT) url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| DocumentTitleAlternate | Ioanna Pavlaki et al |
| EISSN | 1460-2075 |
| EndPage | n/a |
| ExternalDocumentID | PMC5978383 29661885 EMBJ201798219 10_15252_embj_201798219 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Wellcome grantid: 106956/Z/15/Z funderid: 10.13039/100010269 – fundername: H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC) grantid: 249869 funderid: 10.13039/100010663 – fundername: RCUK | Medical Research Council (MRC) grantid: MR/M010554/1; MC_UU_12008/1 funderid: 10.13039/501100000265 – fundername: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) grantid: BB/N005856/1 funderid: 10.13039/501100000268 – fundername: RCUK | Medical Research Council (MRC) funderid: MR/M010554/1; MC_UU_12008/1 – fundername: H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC) funderid: 249869 – fundername: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) funderid: BB/N005856/1 – fundername: Wellcome funderid: 106956/Z/15/Z – fundername: Wellcome Trust grantid: 106956/Z/15/Z – fundername: Wellcome Trust – fundername: Medical Research Council grantid: MC_UU_12008/1 – fundername: Biotechnology and Biological Sciences Research Council grantid: BB/N005856/1 – fundername: European Research Council grantid: 249869 – fundername: Medical Research Council grantid: MC_UU_00007/15 – fundername: Medical Research Council grantid: MR/M010554/1 – fundername: H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC) grantid: 249869 – fundername: Wellcome grantid: 106956/Z/15/Z – fundername: RCUK | Medical Research Council (MRC) grantid: MR/M010554/1; MC_UU_12008/1 – fundername: RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) grantid: BB/N005856/1 |
| GroupedDBID | --- -DZ -Q- -~X 0R~ 123 1OC 24P 29G 2WC 33P 36B 39C 53G 5VS 70F 8R4 8R5 A8Z AAESR AAEVG AAHBH AAHHS AAIHA AAJSJ AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCUV ABLJU ACAHQ ACCFJ ACCZN ACGFO ACGFS ACNCT ACPOU ACPRK ACXBN ACXQS ADBBV ADEOM ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AENEX AEQDE AEUYR AFBPY AFFNX AFGKR AFPWT AFRAH AFWVQ AFZJQ AHMBA AIAGR AIURR AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOIJS AUFTA AZBYB AZFZN AZVAB BAWUL BDRZF BENPR BFHJK BMNLL BMXJE BRXPI BTFSW C6C CS3 DCZOG DIK DPXWK DRFUL DRSTM DU5 E3Z EBD EBLON EBS EJD EMB EMOBN F5P G-S GROUPED_DOAJ GX1 HH5 HK~ HYE KQ8 LATKE LEEKS LITHE LOXES LUTES LYRES MEWTI MRFUL MRSTM MSFUL MSSTM MVM MXFUL MXSTM MY~ O9- OK1 P2P P2W Q2X R.K RHF RHI RNS ROL RPM SV3 TN5 TR2 WBKPD WH7 WIH WIK WIN WOHZO WXSBR WYJ YSK ZCA ZZTAW ~KM AAMMB AASML ABZEH AEFGJ AGXDD AIDQK AIDYY AJAOE ESTFP NAO CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-p3019-4d54412f02410fefbb27c203112cb0b31c5a44e92c111cc79edb440cb4c3842d3 |
| IEDL.DBID | 24P |
| ISSN | 0261-4189 1460-2075 |
| IngestDate | Tue Sep 30 16:36:23 EDT 2025 Wed Oct 01 12:03:54 EDT 2025 Mon Oct 06 17:24:37 EDT 2025 Mon Jul 21 06:03:08 EDT 2025 Tue Nov 11 03:10:16 EST 2025 Fri Feb 21 02:37:31 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | neurogenesis lncRNA KAP1 chromatin gene regulation |
| Language | English |
| License | Attribution 2018 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p3019-4d54412f02410fefbb27c203112cb0b31c5a44e92c111cc79edb440cb4c3842d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work |
| ORCID | 0000-0002-3411-8213 0000-0003-2514-0977 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fembj.201798219 |
| PMID | 29661885 |
| PQID | 2047314162 |
| PQPubID | 35985 |
| PageCount | 16 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5978383 proquest_miscellaneous_2026421272 proquest_journals_2047314162 pubmed_primary_29661885 wiley_primary_10_15252_embj_201798219_EMBJ201798219 springer_journals_10_15252_embj_201798219 |
| PublicationCentury | 2000 |
| PublicationDate | 15 May 2018 |
| PublicationDateYYYYMMDD | 2018-05-15 |
| PublicationDate_xml | – month: 05 year: 2018 text: 15 May 2018 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York – name: Hoboken |
| PublicationTitle | The EMBO journal |
| PublicationTitleAbbrev | EMBO J |
| PublicationTitleAlternate | EMBO J |
| PublicationYear | 2018 |
| Publisher | Nature Publishing Group UK Springer Nature B.V John Wiley and Sons Inc |
| Publisher_xml | – name: Nature Publishing Group UK – name: Springer Nature B.V – name: John Wiley and Sons Inc |
| References | Chang, Adorjan, Mundim, Sun, Dizon, Szele (CR8) 2016; 10 Engreitz, Haines, Perez, Munson, Chen, Kane, McDonel, Guttman, Lander (CR17) 2016; 539 Doetsch, Caille, Lim, Garcia‐Verdugo, Alvarez‐Buylla (CR15) 1999; 97 Hsieh, Yao, Lai, Yang (CR21) 2006; 349 Herzog, Wendling, Guillou, Chambon, Mark, Losson, Cammas (CR20) 2011; 350 Ramirez, Ryan, Gruning, Bhardwaj, Kilpert, Richter, Heyne, Dundar, Manke (CR41) 2016; 44 Ponjavic, Oliver, Lunter, Ponting (CR38) 2009; 5 Heger, Webber, Goodson, Ponting, Lunter (CR19) 2013; 29 Pataskar, Jung, Smialowski, Noack, Calegari, Straub, Tiwari (CR36) 2016; 35 Pradeepa, McKenna, Taylor, Bengani, Grimes, Wood, Bhatia, Bickmore (CR40) 2017; 13 Petreanu, Alvarez‐Buylla (CR37) 2002; 22 Davidovich, Wang, Cifuentes‐Rojas, Goodrich, Gooding, Lee, Cech (CR12) 2015; 57 Bolger, Lohse, Usadel (CR2) 2014; 30 Chesler, Le Pichon, Brann, Araneda, Zou, Firestein (CR9) 2008; 3 Dizon, Shin, Sundholm‐Peters, Kang, Szele (CR14) 2006; 142 Lledo, Saghatelyan (CR27) 2005; 28 Ding, Wang, Lin, Xing, Ge, Jia, Zhang, Fan, Li (CR13) 2016; 590 Yang, Flynn, Chen, Qu, Wan, Wang, Lei, Chang (CR54) 2014; 3 Okonechnikov, Conesa, Garcia‐Alcalde (CR34) 2016; 32 Li, Durbin (CR26) 2010; 26 Carlson, Quinn, Yang, Thornburg, Chang, Stadler (CR6) 2015; 11 O'Geen, Ren, Nicolet, Perez, Halmai, Le, Mackay, Farnham, Segal (CR33) 2017; 45 Kaneko, Son, Shen, Reinberg, Bonasio (CR25) 2013; 20 Boutin, Diestel, Desoeuvre, Tiveron, Cremer (CR3) 2008; 3 Schultz, Ayyanathan, Negorev, Maul, Rauscher (CR44) 2002; 16 Vance, Sansom, Lee, Chalei, Kong, Cooper, Oliver, Ponting (CR48) 2014; 33 Yin, Yan, Lu, Song, Zhu, Li, Zhao, Shen, Huang, Zhu, Orkin, Shen (CR55) 2015; 16 O'Geen, Squazzo, Iyengar, Blahnik, Rinn, Chang, Green, Farnham (CR32) 2007; 3 Nowak, Tian, Brasier (CR31) 2005; 39 Vance (CR49) 2016; 1468 Chu, Qu, Zhong, Artandi, Chang (CR10) 2011; 44 Iyengar, Farnham (CR23) 2011; 286 Mercer, Qureshi, Gokhan, Dinger, Li, Mattick, Mehler (CR30) 2010; 11 Gheusi, Cremer, McLean, Chazal, Vincent, Lledo (CR18) 2000; 97 Boutin, Hardt, de Chevigny, Core, Goebbels, Seidenfaden, Bosio, Cremer (CR4) 2010; 107 Yang, Lin, Jin, Yang, Tanasa, Li, Merkurjev, Ohgi, Meng, Zhang, Evans, Rosenfeld (CR52) 2013; 500 Vance, Ponting (CR47) 2014; 30 Bardella, Al‐Dalahmah, Krell, Brazauskas, Al‐Qahtani, Tomkova, Adam, Serres, Lockstone, Freeman‐Mills, Pfeffer, Sibson, Goldin, Schuster‐Boeckler, Pollard, Soga, McCullagh, Schofield, Mulholland, Ansorge (CR1) 2016; 30 Rutenberg‐Schoenberg, Sexton, Simon (CR43) 2016; 17 Cammas, Mark, Dolle, Dierich, Chambon, Losson (CR5) 2000; 127 Mercer, Dinger, Sunkin, Mehler, Mattick (CR29) 2008; 105 Ilik, Quinn, Georgiev, Tavares‐Cadete, Maticzka, Toscano, Wan, Spitale, Luscombe, Backofen, Chang, Akhtar (CR22) 2013; 51 Orom, Derrien, Beringer, Gumireddy, Gardini, Bussotti, Lai, Zytnicki, Notredame, Huang, Guigo, Shiekhattar (CR35) 2010; 143 Yang, Sundholm‐Peters, Goings, Walker, Hyland, Szele (CR51) 2004; 76 Maenner, Muller, Frohlich, Langer, Becker (CR28) 2013; 51 West, Davis, Sunwoo, Simon, Sadreyev, Wang, Tolstorukov, Kingston (CR50) 2014; 55 Chalei, Sansom, Kong, Lee, Montiel, Vance, Ponting (CR7) 2014; 3 Iyengar, Ivanov, Jin, Rauscher, Farnham (CR24) 2011; 31 Shibata, Blauvelt, Liem, Garcia‐Garcia (CR45) 2011; 138 Portoso, Ragazzini, Brencic, Moiani, Michaud, Vassilev, Wassef, Servant, Sargueil, Margueron (CR39) 2017; 36 Tsai, Manor, Wan, Mosammaparast, Wang, Lan, Shi, Segal, Chang (CR46) 2010; 329 Yang, Song, Cheng, Wu, Bhagat, Yu, Abraham, Ibrahim, Ravich, Roland, Khashab, Singh, Shin, Yang, Verma, Meltzer, Mori (CR53) 2014; 63 (CR16) 2012; 489 Ramos, Diaz, Nellore, Delgado, Park, Gonzales‐Roybal, Oldham, Song, Lim (CR42) 2013; 12 Young, Al‐Dalahmah, Lewis, Brooks, Jenkins, Poirier, Buchan, Szele (CR56) 2014; 63 Comte, Kim, Young, van der Harg, Hockberger, Bolam, Poirier, Szele (CR11) 2011; 124 Zhao, Ohsumi, Kung, Ogawa, Grau, Sarma, Song, Kingston, Borowsky, Lee (CR57) 2010; 40 2002; 16 2014b; 3 2013; 29 2010; 11 2010; 107 2013; 20 2017; 45 2016; 32 2010; 143 2016; 30 2008; 105 2008; 3 2011; 350 2014; 63 2012; 489 2005; 28 2016; 35 2004; 76 2011; 124 2010; 26 2014; 3 2017; 36 2000; 127 2013; 12 2013; 51 2000; 97 1999; 97 2007; 3 2014a; 63 2005; 39 2014; 55 2011; 286 2016; 590 2016; 44 2015; 57 2011; 138 2015; 16 2010; 329 2013; 500 2015; 11 2016; 10 2011; 31 2016; 1468 2016; 17 2010; 40 2016; 539 2017; 13 2002; 22 2011; 44 2006; 142 2009; 5 2014; 30 2006; 349 2014; 33 |
| References_xml | – volume: 20 start-page: 1258 year: 2013 end-page: 1264 ident: CR25 article-title: PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells publication-title: Nat Struct Mol Biol – volume: 63 start-page: 881 year: 2014 end-page: 890 ident: CR53 article-title: Long non‐coding RNA HNF1A‐AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells publication-title: Gut – volume: 32 start-page: 292 year: 2016 end-page: 294 ident: CR34 article-title: Qualimap 2: advanced multi‐sample quality control for high‐throughput sequencing data publication-title: Bioinformatics – volume: 13 start-page: e1006677 year: 2017 ident: CR40 article-title: Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip publication-title: PLoS Genet – volume: 51 start-page: 174 year: 2013 end-page: 184 ident: CR28 article-title: ATP‐dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins publication-title: Mol Cell – volume: 97 start-page: 1823 year: 2000 end-page: 1828 ident: CR18 article-title: Importance of newly generated neurons in the adult olfactory bulb for odor discrimination publication-title: Proc Natl Acad Sci USA – volume: 30 start-page: 348 year: 2014 end-page: 355 ident: CR47 article-title: Transcriptional regulatory functions of nuclear long noncoding RNAs publication-title: Trends Genet – volume: 51 start-page: 156 year: 2013 end-page: 173 ident: CR22 article-title: Tandem stem‐loops in roX RNAs act together to mediate X chromosome dosage compensation in publication-title: Mol Cell – volume: 349 start-page: 573 year: 2006 end-page: 581 ident: CR21 article-title: Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1 publication-title: Biochem Biophys Res Comm – volume: 63 start-page: 155 year: 2014 end-page: 164 ident: CR56 article-title: Blocked angiogenesis in Galectin‐3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke publication-title: Neurobiol Dis – volume: 40 start-page: 939 year: 2010 end-page: 953 ident: CR57 article-title: Genome‐wide identification of polycomb‐associated RNAs by RIP‐seq publication-title: Mol Cell – volume: 44 start-page: 667 year: 2011 end-page: 678 ident: CR10 article-title: Genomic maps of long noncoding RNA occupancy reveal principles of RNA‐chromatin interactions publication-title: Mol Cell – volume: 539 start-page: 452 year: 2016 end-page: 455 ident: CR17 article-title: Local regulation of gene expression by lncRNA promoters, transcription and splicing publication-title: Nature – volume: 3 start-page: e02046 year: 2014 ident: CR54 article-title: Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency publication-title: eLife – volume: 127 start-page: 2955 year: 2000 end-page: 2963 ident: CR5 article-title: Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development publication-title: Development – volume: 10 start-page: 332 year: 2016 ident: CR8 article-title: Traumatic brain injury activation of the adult subventricular zone neurogenic niche publication-title: Front Neurosci – volume: 124 start-page: 2438 year: 2011 end-page: 2447 ident: CR11 article-title: Galectin‐3 maintains cell motility from the subventricular zone to the olfactory bulb publication-title: J Cell Sci – volume: 26 start-page: 589 year: 2010 end-page: 595 ident: CR26 article-title: Fast and accurate long‐read alignment with Burrows‐Wheeler transform publication-title: Bioinformatics – volume: 39 start-page: 715 year: 2005 end-page: 725 ident: CR31 article-title: Two‐step cross‐linking method for identification of NF‐kappaB gene network by chromatin immunoprecipitation publication-title: Biotechniques – volume: 35 start-page: 24 year: 2016 end-page: 45 ident: CR36 article-title: NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program publication-title: EMBO J – volume: 33 start-page: 296 year: 2014 end-page: 311 ident: CR48 article-title: The long non‐coding RNA Paupar regulates the expression of both local and distal genes publication-title: EMBO J – volume: 138 start-page: 5333 year: 2011 end-page: 5343 ident: CR45 article-title: TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra‐embryonic tissues publication-title: Development – volume: 489 start-page: 57 year: 2012 end-page: 74 ident: CR16 article-title: An integrated encyclopedia of DNA elements in the human genome publication-title: Nature – volume: 11 start-page: 14 year: 2010 ident: CR30 article-title: Long noncoding RNAs in neuronal‐glial fate specification and oligodendrocyte lineage maturation publication-title: BMC Neurosci – volume: 107 start-page: 1201 year: 2010 end-page: 1206 ident: CR4 article-title: NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis publication-title: Proc Natl Acad Sci USA – volume: 105 start-page: 716 year: 2008 end-page: 721 ident: CR29 article-title: Specific expression of long noncoding RNAs in the mouse brain publication-title: Proc Natl Acad Sci USA – volume: 55 start-page: 791 year: 2014 end-page: 802 ident: CR50 article-title: The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites publication-title: Mol Cell – volume: 97 start-page: 703 year: 1999 end-page: 716 ident: CR15 article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain publication-title: Cell – volume: 44 start-page: W160 year: 2016 end-page: W165 ident: CR41 article-title: deepTools2: a next generation web server for deep‐sequencing data analysis publication-title: Nucleic Acids Res – volume: 5 start-page: e1000617 year: 2009 ident: CR38 article-title: Genomic and transcriptional co‐localization of protein‐coding and long non‐coding RNA pairs in the developing brain publication-title: PLoS Genet – volume: 143 start-page: 46 year: 2010 end-page: 58 ident: CR35 article-title: Long noncoding RNAs with enhancer‐like function in human cells publication-title: Cell – volume: 329 start-page: 689 year: 2010 end-page: 693 ident: CR46 article-title: Long noncoding RNA as modular scaffold of histone modification complexes publication-title: Science – volume: 590 start-page: 1729 year: 2016 end-page: 1738 ident: CR13 article-title: PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma publication-title: FEBS Lett – volume: 16 start-page: 919 year: 2002 end-page: 932 ident: CR44 article-title: SETDB1: a novel KAP‐1‐associated histone H3, lysine 9‐specific methyltransferase that contributes to HP1‐mediated silencing of euchromatic genes by KRAB zinc‐finger proteins publication-title: Genes Dev – volume: 57 start-page: 552 year: 2015 end-page: 558 ident: CR12 article-title: Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA publication-title: Mol Cell – volume: 1468 start-page: 39 year: 2016 end-page: 50 ident: CR49 article-title: Mapping long non‐coding RNA chromatin occupancy using Capture Hybridization Analysis of RNA Targets (CHART) publication-title: Methods Mol Biol – volume: 11 start-page: e1005680 year: 2015 ident: CR6 article-title: LncRNA‐HIT functions as an epigenetic regulator of chondrogenesis through its recruitment of p100/CBP complexes publication-title: PLoS Genet – volume: 142 start-page: 717 year: 2006 end-page: 725 ident: CR14 article-title: Subventricular zone cells remain stable after brain injury publication-title: Neuroscience – volume: 3 start-page: e1517 year: 2008 ident: CR9 article-title: Selective gene expression by postnatal electroporation during olfactory interneuron neurogenesis publication-title: PLoS One – volume: 28 start-page: 248 year: 2005 end-page: 254 ident: CR27 article-title: Integrating new neurons into the adult olfactory bulb: joining the network, life‐death decisions, and the effects of sensory experience publication-title: Trends Neurosci – volume: 36 start-page: 981 year: 2017 end-page: 994 ident: CR39 article-title: PRC2 is dispensable for HOTAIR‐mediated transcriptional repression publication-title: EMBO J – volume: 29 start-page: 2046 year: 2013 end-page: 2048 ident: CR19 article-title: GAT: a simulation framework for testing the association of genomic intervals publication-title: Bioinformatics – volume: 22 start-page: 6106 year: 2002 end-page: 6113 ident: CR37 article-title: Maturation and death of adult‐born olfactory bulb granule neurons: role of olfaction publication-title: J Neurosci – volume: 31 start-page: 1833 year: 2011 end-page: 1847 ident: CR24 article-title: Functional analysis of KAP1 genomic recruitment publication-title: Mol Cell Biol – volume: 17 start-page: 69 year: 2016 end-page: 94 ident: CR43 article-title: The properties of long noncoding RNAs that regulate chromatin publication-title: Annu Rev Genomics Hum Genet – volume: 3 start-page: e04530 year: 2014 ident: CR7 article-title: The long non‐coding RNA Dali is an epigenetic regulator of neural differentiation publication-title: eLife – volume: 30 start-page: 578 year: 2016 end-page: 594 ident: CR1 article-title: Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis publication-title: Cancer Cell – volume: 3 start-page: e89 year: 2007 ident: CR32 article-title: Genome‐wide analysis of KAP1 binding suggests autoregulation of KRAB‐ZNFs publication-title: PLoS Genet – volume: 350 start-page: 548 year: 2011 end-page: 558 ident: CR20 article-title: TIF1beta association with HP1 is essential for post‐gastrulation development, but not for Sertoli cell functions during spermatogenesis publication-title: Dev Biol – volume: 12 start-page: 616 year: 2013 end-page: 628 ident: CR42 article-title: Integration of genome‐wide approaches identifies lncRNAs of adult neural stem cells and their progeny publication-title: Cell Stem Cell – volume: 16 start-page: 504 year: 2015 end-page: 516 ident: CR55 article-title: Opposing roles for the lncRNA Haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation publication-title: Cell Stem Cell – volume: 30 start-page: 2114 year: 2014 end-page: 2120 ident: CR2 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data publication-title: Bioinformatics – volume: 3 start-page: e1883 year: 2008 ident: CR3 article-title: Efficient electroporation of the postnatal rodent forebrain publication-title: PLoS One – volume: 286 start-page: 26267 year: 2011 end-page: 26276 ident: CR23 article-title: KAP1 protein: an enigmatic master regulator of the genome publication-title: J Biol Chem – volume: 76 start-page: 282 year: 2004 end-page: 295 ident: CR51 article-title: Distribution of doublecortin expressing cells near the lateral ventricles in the adult mouse brain publication-title: J Neurosci Res – volume: 45 start-page: 9901 year: 2017 end-page: 9916 ident: CR33 article-title: dCas9‐based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression publication-title: Nucleic Acids Res – volume: 500 start-page: 598 year: 2013 end-page: 602 ident: CR52 article-title: lncRNA‐dependent mechanisms of androgen‐receptor‐regulated gene activation programs publication-title: Nature – volume: 33 start-page: 296 year: 2014 end-page: 311 article-title: The long non‐coding RNA Paupar regulates the expression of both local and distal genes publication-title: EMBO J – volume: 11 start-page: 14 year: 2010 article-title: Long noncoding RNAs in neuronal‐glial fate specification and oligodendrocyte lineage maturation publication-title: BMC Neurosci – volume: 22 start-page: 6106 year: 2002 end-page: 6113 article-title: Maturation and death of adult‐born olfactory bulb granule neurons: role of olfaction publication-title: J Neurosci – volume: 3 start-page: e89 year: 2007 article-title: Genome‐wide analysis of KAP1 binding suggests autoregulation of KRAB‐ZNFs publication-title: PLoS Genet – volume: 17 start-page: 69 year: 2016 end-page: 94 article-title: The properties of long noncoding RNAs that regulate chromatin publication-title: Annu Rev Genomics Hum Genet – volume: 30 start-page: 348 year: 2014 end-page: 355 article-title: Transcriptional regulatory functions of nuclear long noncoding RNAs publication-title: Trends Genet – volume: 105 start-page: 716 year: 2008 end-page: 721 article-title: Specific expression of long noncoding RNAs in the mouse brain publication-title: Proc Natl Acad Sci USA – volume: 32 start-page: 292 year: 2016 end-page: 294 article-title: Qualimap 2: advanced multi‐sample quality control for high‐throughput sequencing data publication-title: Bioinformatics – volume: 3 start-page: e02046 year: 2014b article-title: Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency publication-title: eLife – volume: 16 start-page: 504 year: 2015 end-page: 516 article-title: Opposing roles for the lncRNA Haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation publication-title: Cell Stem Cell – volume: 57 start-page: 552 year: 2015 end-page: 558 article-title: Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA publication-title: Mol Cell – volume: 55 start-page: 791 year: 2014 end-page: 802 article-title: The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites publication-title: Mol Cell – volume: 39 start-page: 715 year: 2005 end-page: 725 article-title: Two‐step cross‐linking method for identification of NF‐kappaB gene network by chromatin immunoprecipitation publication-title: Biotechniques – volume: 124 start-page: 2438 year: 2011 end-page: 2447 article-title: Galectin‐3 maintains cell motility from the subventricular zone to the olfactory bulb publication-title: J Cell Sci – volume: 107 start-page: 1201 year: 2010 end-page: 1206 article-title: NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis publication-title: Proc Natl Acad Sci USA – volume: 3 start-page: e04530 year: 2014 article-title: The long non‐coding RNA Dali is an epigenetic regulator of neural differentiation publication-title: eLife – volume: 1468 start-page: 39 year: 2016 end-page: 50 article-title: Mapping long non‐coding RNA chromatin occupancy using Capture Hybridization Analysis of RNA Targets (CHART) publication-title: Methods Mol Biol – volume: 76 start-page: 282 year: 2004 end-page: 295 article-title: Distribution of doublecortin expressing cells near the lateral ventricles in the adult mouse brain publication-title: J Neurosci Res – volume: 51 start-page: 174 year: 2013 end-page: 184 article-title: ATP‐dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins publication-title: Mol Cell – volume: 63 start-page: 881 year: 2014a end-page: 890 article-title: Long non‐coding RNA HNF1A‐AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells publication-title: Gut – volume: 127 start-page: 2955 year: 2000 end-page: 2963 article-title: Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development publication-title: Development – volume: 489 start-page: 57 year: 2012 end-page: 74 article-title: An integrated encyclopedia of DNA elements in the human genome publication-title: Nature – volume: 349 start-page: 573 year: 2006 end-page: 581 article-title: Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1 publication-title: Biochem Biophys Res Comm – volume: 590 start-page: 1729 year: 2016 end-page: 1738 article-title: PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma publication-title: FEBS Lett – volume: 45 start-page: 9901 year: 2017 end-page: 9916 article-title: dCas9‐based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression publication-title: Nucleic Acids Res – volume: 63 start-page: 155 year: 2014 end-page: 164 article-title: Blocked angiogenesis in Galectin‐3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke publication-title: Neurobiol Dis – volume: 142 start-page: 717 year: 2006 end-page: 725 article-title: Subventricular zone cells remain stable after brain injury publication-title: Neuroscience – volume: 29 start-page: 2046 year: 2013 end-page: 2048 article-title: GAT: a simulation framework for testing the association of genomic intervals publication-title: Bioinformatics – volume: 11 start-page: e1005680 year: 2015 article-title: LncRNA‐HIT functions as an epigenetic regulator of chondrogenesis through its recruitment of p100/CBP complexes publication-title: PLoS Genet – volume: 13 start-page: e1006677 year: 2017 article-title: Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip publication-title: PLoS Genet – volume: 3 start-page: e1517 year: 2008 article-title: Selective gene expression by postnatal electroporation during olfactory interneuron neurogenesis publication-title: PLoS One – volume: 35 start-page: 24 year: 2016 end-page: 45 article-title: NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program publication-title: EMBO J – volume: 97 start-page: 1823 year: 2000 end-page: 1828 article-title: Importance of newly generated neurons in the adult olfactory bulb for odor discrimination publication-title: Proc Natl Acad Sci USA – volume: 36 start-page: 981 year: 2017 end-page: 994 article-title: PRC2 is dispensable for HOTAIR‐mediated transcriptional repression publication-title: EMBO J – volume: 539 start-page: 452 year: 2016 end-page: 455 article-title: Local regulation of gene expression by lncRNA promoters, transcription and splicing publication-title: Nature – volume: 30 start-page: 578 year: 2016 end-page: 594 article-title: Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis publication-title: Cancer Cell – volume: 12 start-page: 616 year: 2013 end-page: 628 article-title: Integration of genome‐wide approaches identifies lncRNAs of adult neural stem cells and their progeny publication-title: Cell Stem Cell – volume: 329 start-page: 689 year: 2010 end-page: 693 article-title: Long noncoding RNA as modular scaffold of histone modification complexes publication-title: Science – volume: 97 start-page: 703 year: 1999 end-page: 716 article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain publication-title: Cell – volume: 26 start-page: 589 year: 2010 end-page: 595 article-title: Fast and accurate long‐read alignment with Burrows‐Wheeler transform publication-title: Bioinformatics – volume: 20 start-page: 1258 year: 2013 end-page: 1264 article-title: PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells publication-title: Nat Struct Mol Biol – volume: 286 start-page: 26267 year: 2011 end-page: 26276 article-title: KAP1 protein: an enigmatic master regulator of the genome publication-title: J Biol Chem – volume: 10 start-page: 332 year: 2016 article-title: Traumatic brain injury activation of the adult subventricular zone neurogenic niche publication-title: Front Neurosci – volume: 30 start-page: 2114 year: 2014 end-page: 2120 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data publication-title: Bioinformatics – volume: 5 start-page: e1000617 year: 2009 article-title: Genomic and transcriptional co‐localization of protein‐coding and long non‐coding RNA pairs in the developing brain publication-title: PLoS Genet – volume: 28 start-page: 248 year: 2005 end-page: 254 article-title: Integrating new neurons into the adult olfactory bulb: joining the network, life‐death decisions, and the effects of sensory experience publication-title: Trends Neurosci – volume: 138 start-page: 5333 year: 2011 end-page: 5343 article-title: TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra‐embryonic tissues publication-title: Development – volume: 143 start-page: 46 year: 2010 end-page: 58 article-title: Long noncoding RNAs with enhancer‐like function in human cells publication-title: Cell – volume: 3 start-page: e1883 year: 2008 article-title: Efficient electroporation of the postnatal rodent forebrain publication-title: PLoS One – volume: 350 start-page: 548 year: 2011 end-page: 558 article-title: TIF1beta association with HP1 is essential for post‐gastrulation development, but not for Sertoli cell functions during spermatogenesis publication-title: Dev Biol – volume: 31 start-page: 1833 year: 2011 end-page: 1847 article-title: Functional analysis of KAP1 genomic recruitment publication-title: Mol Cell Biol – volume: 500 start-page: 598 year: 2013 end-page: 602 article-title: lncRNA‐dependent mechanisms of androgen‐receptor‐regulated gene activation programs publication-title: Nature – volume: 51 start-page: 156 year: 2013 end-page: 173 article-title: Tandem stem‐loops in roX RNAs act together to mediate X chromosome dosage compensation in publication-title: Mol Cell – volume: 44 start-page: W160 year: 2016 end-page: W165 article-title: deepTools2: a next generation web server for deep‐sequencing data analysis publication-title: Nucleic Acids Res – volume: 44 start-page: 667 year: 2011 end-page: 678 article-title: Genomic maps of long noncoding RNA occupancy reveal principles of RNA‐chromatin interactions publication-title: Mol Cell – volume: 16 start-page: 919 year: 2002 end-page: 932 article-title: SETDB1: a novel KAP‐1‐associated histone H3, lysine 9‐specific methyltransferase that contributes to HP1‐mediated silencing of euchromatic genes by KRAB zinc‐finger proteins publication-title: Genes Dev – volume: 40 start-page: 939 year: 2010 end-page: 953 article-title: Genome‐wide identification of polycomb‐associated RNAs by RIP‐seq publication-title: Mol Cell |
| SSID | ssj0005871 |
| Score | 2.4789958 |
| Snippet | Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their
in vivo
roles and mechanisms of action remain... Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain... Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their roles and mechanisms of action remain poorly... Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain... Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain... |
| SourceID | pubmedcentral proquest pubmed wiley springer |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| SubjectTerms | Animals Animals, Newborn Cell Cycle Cell Proliferation Cells, Cultured Central nervous system Chromatin Chromatin - genetics Deposition EMBO09 EMBO27 EMBO36 Epigenesis, Genetic Epigenetics Gene expression gene regulation Genes Genomes Genomics KAP1 lncRNA Mice Neural Stem Cells - cytology Neural Stem Cells - metabolism Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neurogenesis Non-coding RNA Olfaction Olfactory bulb Olfactory Bulb - cytology Olfactory Bulb - metabolism Pax6 protein PAX6 Transcription Factor - genetics PAX6 Transcription Factor - metabolism Proteins Regulators Regulatory Elements, Transcriptional Regulatory sequences Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Transcription factors Tripartite Motif-Containing Protein 28 - genetics Tripartite Motif-Containing Protein 28 - metabolism |
| Title | The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis |
| URI | https://link.springer.com/article/10.15252/embj.201798219 https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fembj.201798219 https://www.ncbi.nlm.nih.gov/pubmed/29661885 https://www.proquest.com/docview/2047314162 https://www.proquest.com/docview/2026421272 https://pubmed.ncbi.nlm.nih.gov/PMC5978383 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library customDbUrl: eissn: 1460-2075 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005871 issn: 0261-4189 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1460-2075 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0005871 issn: 0261-4189 databaseCode: WIN dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELbQLgguPJbHBpaVkbhwiIgdN3aOZdmKZ1WtWNFbZDtOt6ibVE0L2hs_gZ_Ab-Gn8EuYcR6rCrggLlGimVhx5uGxPZ6PkKfMSqMKocOcMxcKHadgczkPE1PoVEQWIbc92IQcj9V0mk7abEI8C9PUh-gX3NAyvL9GA9em7hB7sGqoOzefMDdLpopj4c9dxmKJis3F5DLLQ_k5l19mEUylbXUfbOL5dgN_CjF_z5Tst0u3g1k_Go1u_Yd-3CY321CUDhvduUOuuHKPXGvAKS_2yPWjDgvuLvkC2kQXVTmjZVX-_PrNVjjk0ZPxkE70ZqlXdOnT-lxN3w4nDDg6cN01tWdAAvmXtDlkXFNd5nTlZggc5uof36tFA_pzQc1mYaivsDlDFzyv75HT0fGHo1dhC9kQLsFTpKHIEdOMFzDys6hwhTFcWg6Og3FrIhMzO9BCuJRb8LHWytTlRoBKGGFjJXge3yc70BG3T2iUs8RpaRxzGqhJKiHyNFY7nSiVRGlADjp5Za3d1RmPhIwZBJk8IE96Mvws3AbRpas2yMPxdC-XwPOgEW-2bEp7ZBxmf0ypQUDkluB7BqzGvU0p52e-KvcAF9FUHJBnnYpcfhbOtFDaGco662UdkNhrRt_6X_iy4_cv3vRPD__prUfkBtwrTHxggwOys15t3GNy1X5ez-vVoTcauMqpOiS7L09Gp-_g6ePr8S8ySx-B |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwEB6hLahc-Cl_gQJG4sIhInacxD4upatCt6uqaqXeIttxtouWZLXZBfXGI_AIPAuPwpPgyV9ZARfEMZmJFWd-PJ6M5wN4SU2iRc6VnzFqfa5C6WwuY36scyV5YBByuwabSCYTcX4ufz0L0_SH6BNuaBm1v0YDx4R0B9mDbUPtR_0Bi7MSKRh2_tziTpmiAWy9PRmdja8KPUS97aozLZwK2Tb4wUFebw7xpyjz92LJ_o_pZjxbL0ij2_9jKnfgVhuOkmGjP3fhmi124EYDUHm5A9t7HR7cPfjsNIrMy2JKirL48eWrKXHZIyeTITlW64VakkVd2mcrcjg8po6jA9hdEXPhSE4HCtIcNK6IKjKytFMED7PV92_lvAH-uSR6Pdek7rI5RTc8q-7D2Wj_dO_Ab2Eb_IXzFtLnGeKasdyt_jTIba41SwxzzoMyowMdUhMpzq1kxvlZYxJpM82dWmhuQsFZFj6AgZuIfQQkyGhsVaIttcpRY5m46FMbZVUsRBxID3Y7gaWt7VUpC3gSUhdoMg9e9GT3sfBXiCpsuUYehid8WeJ4HjbyTRdNe4-UuR0gFSLyINmQfM-AHbk3KcXsou7MHWEiTYQevOp05Oq1cLeF0k5R1mkvaw_CWjX60f_Cl-4fvXnfXz3-p6eew_bB6dE4Hb-bHD6Bm-6-wEIIGu3CYLVc26dw3Xxazarls9aGfgLfHyFn |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LjtMwFL1Cw3PDY3gFBjASGxbRxI4TO8syTAUMVBUCaXaR7TidopJETQuaHZ_AJ_AtfApfgq_TZKiADWKZ-MaKcx--dq7PAXhCjdCy5CosGLUhV3HmfK5gYapLlfHIIOW2J5sQk4k8Ps5-PQvT4UMMG27oGT5eo4Pbpih7yh6EDbUf9QcszhKZZIj8eZ4nLtIiujOfnpV5SL_o8vssnMpsA--DXexvd_CnHPP3Usnhf-l2Nuuno_G1_zGQ63B1k4ySUWc9N-CcrXbhYkdPeboLlw96Nrib8NnZE1nU1YxUdfXjy1dT46RH3k5GZKrWjVqSxhf22ZYcjabUSfT0uitiTlyTs4CKdMeMW6KqgiztDKnDbPv9W73oaH9OiV4vNPEYmzMMwvP2FrwfH747eBFuSBvCxsWKLOQFspqx0s39NCptqTUThrnQQZnRkY6pSRTnNmPGRVljRGYLzZ1RaG5iyVkR34YdNxB7F0hU0NQqoS21yrWmmXC5pzbKqlTKNMoC2OsVlm88r81ZxEVMXZrJAng8NLuPhT9CVGXrNcowPN_LhJO50-k3bzpwj5y59R-VMglAbGl-EEA87u2Wan7icbkT3EaTcQBPexs5ey1ca6G2c9R1Pug6gNibxtD7X-TywzfPXg1X9_7pqUdwafp8nL9-OTm6D1fcbYlVEDTZg53Vcm0fwAXzaTVvlw-9A_0EIhUfUA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+long+non%E2%80%90coding+RNA+Paupar+promotes+KAP1%E2%80%90dependent+chromatin+changes+and+regulates%C2%A0olfactory+bulb+neurogenesis&rft.jtitle=The+EMBO+journal&rft.au=Pavlaki%2C+Ioanna&rft.au=Alammari%2C+Farah&rft.au=Sun%2C+Bin&rft.au=Clark%2C+Neil&rft.date=2018-05-15&rft.issn=0261-4189&rft.eissn=1460-2075&rft.volume=37&rft.issue=10&rft.epage=n%2Fa&rft_id=info:doi/10.15252%2Fembj.201798219&rft.externalDBID=10.15252%252Fembj.201798219&rft.externalDocID=EMBJ201798219 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0261-4189&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0261-4189&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0261-4189&client=summon |