Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis

Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated with unfavourable treatment outcomes. We aimed to investigate estimates and determinants of first-line anti-TB drug pharmacokinetics in children and adolescents at a global level. We systematically searched MEDLINE, Embase a...

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Published in:	The European respiratory journal Vol. 61; no. 3
Main Authors:	Gafar, Fajri, Wasmann, Roeland E, McIlleron, Helen M, Aarnoutse, Rob E, Schaaf, H Simon, Marais, Ben J, Agarwal, Dipti, Antwi, Sampson, Bang, Nguyen D, Bekker, Adrie, Bell, David J, Chabala, Chishala, Choo, Louise, Davies, Geraint R, Day, Jeremy N, Dayal, Rajeshwar, Denti, Paolo, Donald, Peter R, Engidawork, Ephrem, Garcia-Prats, Anthony J, Gibb, Diana, Graham, Stephen M, Hesseling, Anneke C, Heysell, Scott K, Idris, Misgana I, Kabra, Sushil K, Kinikar, Aarti, Kumar, Agibothu K Hemanth, Kwara, Awewura, Lodha, Rakesh, Magis-Escurra, Cecile, Martinez, Nilza, Mathew, Binu S, Mave, Vidya, Mduma, Estomih, Mlotha-Mitole, Rachel, Mpagama, Stellah G, Mukherjee, Aparna, Nataprawira, Heda M, Peloquin, Charles A, Pouplin, Thomas, Ramachandran, Geetha, Ranjalkar, Jaya, Roy, Vandana, Ruslami, Rovina, Shah, Ira, Singh, Yatish, Sturkenboom, Marieke G G, Svensson, Elin M, Swaminathan, Soumya, Thatte, Urmila, Thee, Stephanie, Thomas, Tania A, Tikiso, Tjokosela, Touw, Daan J, Turkova, Anna, Velpandian, Thirumurthy, Verhagen, Lilly M, Winckler, Jana L, Yang, Hongmei, Yunivita, Vycke, Taxis, Katja, Stevens, Jasper, Alffenaar, Jan-Willem C
Format:	Journal Article
Language:	English
Published:	England 01.03.2023
Subjects:	Adolescent Antitubercular Agents - therapeutic use Child Child, Preschool Ethambutol - therapeutic use Humans Isoniazid - therapeutic use Pyrazinamide - therapeutic use Rifampin - therapeutic use
ISSN:	1399-3003, 1399-3003
Online Access:	Get more information
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