Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the most prevalent and highly aggressive liver malignancy with limited therapeutic options. Here, the therapeutic potential of zerumbone, a sesquiterpene derived from the ginger plant , against HCC was explored. Zerumbone inhibited proliferation and clonogenic survi...

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Veröffentlicht in:	Molecular cancer research Jg. 16; H. 2; S. 256
Hauptverfasser:	Wani, Nissar Ahmad, Zhang, Bo, Teng, Kun-Yu, Barajas, Juan M, Motiwala, Tasneem, Hu, Peng, Yu, Lianbo, Brüschweiler, Rafael, Ghoshal, Kalpana, Jacob, Samson T
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2018
Schlagworte:	Animals Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Gene Expression Profiling - methods Gene Regulatory Networks - drug effects Glucose - metabolism Glycolysis - drug effects Hep G2 Cells Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Male Mice Sesquiterpenes - administration & dosage Sesquiterpenes - pharmacology Signal Transduction - drug effects Xenograft Model Antitumor Assays
ISSN:	1557-3125, 1557-3125
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