Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells

Sulforaphane (SFN) extracted from broccoli sprout has previously been investigated for its potential properties in cancers, however, the underlying mechanisms of the anticancer activity of SFN remain not fully understood. In the present study, we investigate the effects of SFN on cell proliferation,...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; p. 2504
Main Authors:	Wang, Yuan, Wu, Huazhang, Dong, Nannan, Su, Xu, Duan, Mingxiu, Wei, Yaqin, Wei, Jun, Liu, Gaofeng, Peng, Qingjie, Zhao, Yunli
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 28.01.2021 Nature Publishing Group UK
Subjects:	Anticarcinogenic Agents - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Apoptosis - genetics Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism Caspase-3 Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cyclin-dependent kinase 2 Dose-Response Relationship, Drug Flow cytometry Gastric cancer Humans Isothiocyanates - pharmacology p53 Protein Phase transitions S phase S Phase Cell Cycle Checkpoints - drug effects S Phase Cell Cycle Checkpoints - genetics Stomach Neoplasms Sulforaphane Sulfoxides - pharmacology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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