Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts

Interstitial renal fibrosis is a major pathophysiological manifestation of patients diagnosed with Chronic Kidney Disease (CKD), Diabetic Nephropathy (DN) and other inflammatory diseases. Adenosine signaling is an innate autocrine and paracrine cellular signaling pathway involving several key mediat...

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Vydané v:	Annals of clinical and laboratory science Ročník 46; číslo 4; s. 339
Hlavní autori:	Wilkinson, Patrick F, Farrell, Francis X, Morel, Diane, Law, William, Murphy, Suzanne
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.07.2016
Predmet:	Adenosine - metabolism Animals Cell Line Cyclic AMP - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Inflammation Mediators - metabolism Intracellular Space - metabolism Kidney - pathology Rats Receptor, Adenosine A1 - genetics Receptor, Adenosine A1 - metabolism Receptor, Adenosine A2B - genetics Receptor, Adenosine A2B - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Adenosine Adenosine receptor 2B inflammation fibrosis cAMP myofibroblasts SMA-a renal fibroblasts
ISSN:	1550-8080, 1550-8080
On-line prístup:	Zistit podrobnosti o prístupe
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