Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts

Interstitial renal fibrosis is a major pathophysiological manifestation of patients diagnosed with Chronic Kidney Disease (CKD), Diabetic Nephropathy (DN) and other inflammatory diseases. Adenosine signaling is an innate autocrine and paracrine cellular signaling pathway involving several key mediat...

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Bibliographic Details
Published in:	Annals of clinical and laboratory science Vol. 46; no. 4; p. 339
Main Authors:	Wilkinson, Patrick F, Farrell, Francis X, Morel, Diane, Law, William, Murphy, Suzanne
Format:	Journal Article
Language:	English
Published:	United States 01.07.2016
Subjects:	Adenosine - metabolism Animals Cell Line Cyclic AMP - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Inflammation Mediators - metabolism Intracellular Space - metabolism Kidney - pathology Rats Receptor, Adenosine A1 - genetics Receptor, Adenosine A1 - metabolism Receptor, Adenosine A2B - genetics Receptor, Adenosine A2B - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Adenosine Adenosine receptor 2B inflammation fibrosis cAMP myofibroblasts SMA-a renal fibroblasts
ISSN:	1550-8080, 1550-8080
Online Access:	Get more information
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