Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns

The risk of spillover of enzootic paramyxoviruses and the susceptibility of recipient human and domestic animal populations are defined by a broad collection of ecological and molecular factors that interact in ways that are not yet fully understood. Nipah and Hendra viruses were the first highly le...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Advances in virus research Ročník 98; s. 1
Hlavní autoři: Thibault, Patricia A, Watkinson, Ruth E, Moreira-Soto, Andres, Drexler, Jan F, Lee, Benhur
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 2017
Témata:
Animals
Cats
Chiroptera - virology
Disease Resistance - genetics
Disease Susceptibility - immunology
Disease Vectors
Dogs
Host-Pathogen Interactions
Humans
Paramyxoviridae Infections - epidemiology
Paramyxoviridae Infections - immunology
Paramyxoviridae Infections - transmission
Paramyxoviridae Infections - veterinary
Paramyxovirinae - classification
Paramyxovirinae - genetics
Paramyxovirinae - pathogenicity
Phylogeny
Rodentia - virology
Zoonoses - epidemiology
Zoonoses - immunology
Zoonoses - transmission
Zoonoses - virology
Tropism
Pathogenesis
Rubulavirus
Emerging viruses
Morbillivirus
Reservoir
Ecology
Zoonotic
Henipavirus
Paramyxovirus
ISSN:1557-8399, 1557-8399
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The risk of spillover of enzootic paramyxoviruses and the susceptibility of recipient human and domestic animal populations are defined by a broad collection of ecological and molecular factors that interact in ways that are not yet fully understood. Nipah and Hendra viruses were the first highly lethal zoonotic paramyxoviruses discovered in modern times, but other paramyxoviruses from multiple genera are present in bats and other reservoirs that have unknown potential to spillover into humans. We outline our current understanding of paramyxovirus reservoir hosts and the ecological factors that may drive spillover, and we explore the molecular barriers to spillover that emergent paramyxoviruses may encounter. By outlining what is known about enzootic paramyxovirus receptor usage, mechanisms of innate immune evasion, and other host-specific interactions, we highlight the breadth of unexplored avenues that may be important in understanding paramyxovirus emergence.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1557-8399
1557-8399
DOI:10.1016/bs.aivir.2016.12.001