Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle

1. The effects of NS 1619, the putative BKCa channel opener, were investigated on rat intact portal veins and on single smooth muscle cells enzymatically separated from the same tissue. 2. Under whole-cell patch clamp conditions with K-rich pipettes, exposure of single cells held at -10 mV to NS 161...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 113; no. 4; p. 1538
Main Authors:	Edwards, G, Niederste-Hollenberg, A, Schneider, J, Noack, T, Weston, A H
Format:	Journal Article
Language:	English
Published:	England 01.12.1994
Subjects:	Animals Benzimidazoles - pharmacology Calcium Channel Agonists - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Charybdotoxin Electrophysiology In Vitro Techniques Male Membrane Potentials - drug effects Muscle Contraction - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Mycotoxins - pharmacology Patch-Clamp Techniques Portal Vein - drug effects Portal Vein - metabolism Potassium Channels - drug effects Potassium Channels - metabolism Rats Rats, Sprague-Dawley Scorpion Venoms - pharmacology
ISSN:	0007-1188
Online Access:	Get more information
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