Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle

1. The effects of NS 1619, the putative BKCa channel opener, were investigated on rat intact portal veins and on single smooth muscle cells enzymatically separated from the same tissue. 2. Under whole-cell patch clamp conditions with K-rich pipettes, exposure of single cells held at -10 mV to NS 161...

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Veröffentlicht in:	British journal of pharmacology Jg. 113; H. 4; S. 1538
Hauptverfasser:	Edwards, G, Niederste-Hollenberg, A, Schneider, J, Noack, T, Weston, A H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.12.1994
Schlagworte:	Animals Benzimidazoles - pharmacology Calcium Channel Agonists - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Charybdotoxin Electrophysiology In Vitro Techniques Male Membrane Potentials - drug effects Muscle Contraction - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Mycotoxins - pharmacology Patch-Clamp Techniques Portal Vein - drug effects Portal Vein - metabolism Potassium Channels - drug effects Potassium Channels - metabolism Rats Rats, Sprague-Dawley Scorpion Venoms - pharmacology
ISSN:	0007-1188
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