Immunological recovery with BIC/FTC/TAF: CD4 T-cell count and CD4/CD8 ratio as markers of response

The CD4/CD8 ratio is a crucial marker of immune dysregulation, immune senescence, and inflammation, predicting outcomes such as non-AIDS conditions and mortality. A low CD4/CD8 ratio is common in late HIV diagnoses, which remain frequent in Italy, where 58% of new cases occur with advanced immune su...

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Bibliographic Details
Published in:The New microbiologica Vol. 48; no. 1; p. 1
Main Authors: Bono, Valeria, Marchetti, Giulia C
Format: Journal Article
Language:English
Published: Italy 01.03.2025
Subjects:
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
CD4 Lymphocyte Count
CD4-CD8 Ratio
Emtricitabine - therapeutic use
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV-1 - drug effects
Humans
Tenofovir - analogs & derivatives
Tenofovir - therapeutic use
Immunological recovery
BIC/FTC/TAF
CD4/CD8 ratio
CD4 T-cell count
ISSN:1121-7138
Online Access:Get more information
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Summary:The CD4/CD8 ratio is a crucial marker of immune dysregulation, immune senescence, and inflammation, predicting outcomes such as non-AIDS conditions and mortality. A low CD4/CD8 ratio is common in late HIV diagnoses, which remain frequent in Italy, where 58% of new cases occur with advanced immune suppression (CD4 <350 cells/μL). Recent advancements in cART, particularly bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF), have demonstrated superior efficacy in restoring immune function, especially in late-stage HIV. BIC/FTC/TAF offers high virological suppression, durable immune reconstitution, and a favorable safety profile. Comparative studies highlight its advantages in improving CD4 counts, reducing HIV RNA, and mitigating inflammatory markers, suggesting potential cardiovascular benefits. These findings position BIC/FTC/TAF as an effective option for advanced HIV treatment, contributing to better immune recovery and reduced systemic inflammation.
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ISSN:1121-7138