Low-dose Radiation Improves Tumor Immune Microenvironment, Enhancing the Effects of Anti-CTLA-4 Therapy

Radiotherapy destroys tumor cells primarily through direct DNA damage by high-energy particles or indirect DNA damage by free radicals. High-dose radiotherapy (HDR) destroys tumor cells while also damaging normal cells and may potentially cause immunosuppression. The effect of low-dose radiotherapy...

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Bibliographic Details
Published in:	Iranian journal of immunology Vol. 22; no. 1; p. 47
Main Authors:	Dong, Jigang, Qi, Ying, Sha, Sha
Format:	Journal Article
Language:	English
Published:	Iran Shiraz Institute for Cancer Research 01.03.2025
Subjects:	Animals Cancer therapies CD8 antigen Cell Line, Tumor Chemokines CTLA-4 Antigen - antagonists & inhibitors CTLA-4 Antigen - immunology CTLA-4 protein CXCL10 protein CXCL11 protein Cytokines - metabolism Disease Models, Animal DNA damage Female Flow cytometry Free radicals Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immune response Immune system Immunosuppression Interferon Lung cancer Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Lung Neoplasms - therapy Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Mice Radiation therapy Tumor cells Tumor microenvironment Tumor Microenvironment - immunology Tumor Microenvironment - radiation effects Tumors Iran United States > US China Low-dose radiotherapy Tumor immune microenvironment Interferon Anti-CTLA-4
ISSN:	1735-1383, 1735-367X, 1735-367X
Online Access:	Get full text
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