New insights into pathways that determine the link between infection and thrombosis

Severe infection is often linked to prothrombotic events. Indeed, haemostatic abnormalities are encountered in most cases of infection, ranging from an increase in sensitive markers for coagulation activation or insignificant laboratory changes to gross activation of coagulation that may result in l...

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Bibliographic Details
Published in:Netherlands journal of medicine Vol. 70; no. 3; p. 114
Main Authors: Levi, M, van der Poll, T, Schultz, M
Format: Journal Article
Language:English
Published: Netherlands 01.04.2012
Subjects:
Blood Coagulation - immunology
Cytokines - immunology
Endothelium, Vascular - immunology
Fibrinolysis
Hemostasis
Humans
Infection - blood
Infection - complications
Thrombosis - etiology
ISSN:1872-9061, 1872-9061
Online Access:Get more information
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Summary:Severe infection is often linked to prothrombotic events. Indeed, haemostatic abnormalities are encountered in most cases of infection, ranging from an increase in sensitive markers for coagulation activation or insignificant laboratory changes to gross activation of coagulation that may result in localised thrombotic complications or disseminated intravascular coagulation. Systemic inflammation as a consequence of infection results in activation of coagulation, due to tissue factor-mediated thrombin generation, down-regulation of physiological anticoagulant mechanisms, and inhibition of fibrinolysis. Pro-inflammatory cytokines, immune cells and the endothelium form the interface on which differential effects on the coagulation and fibrinolysis pathways may ensue. Conversely, activation of the coagulation system may importantly affect inflammatory responses by direct and indirect mechanisms. Apart from the general coagulation response to inflammation associated with severe infection, specific infections may cause distinct features, such as haemorrhagic fever or thrombotic microangiopathy.
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ISSN:1872-9061
1872-9061