New insights into pathways that determine the link between infection and thrombosis

Severe infection is often linked to prothrombotic events. Indeed, haemostatic abnormalities are encountered in most cases of infection, ranging from an increase in sensitive markers for coagulation activation or insignificant laboratory changes to gross activation of coagulation that may result in l...

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Vydané v:Netherlands journal of medicine Ročník 70; číslo 3; s. 114
Hlavní autori: Levi, M, van der Poll, T, Schultz, M
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands 01.04.2012
Predmet:
Blood Coagulation - immunology
Cytokines - immunology
Endothelium, Vascular - immunology
Fibrinolysis
Hemostasis
Humans
Infection - blood
Infection - complications
Thrombosis - etiology
ISSN:1872-9061, 1872-9061
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Shrnutí:Severe infection is often linked to prothrombotic events. Indeed, haemostatic abnormalities are encountered in most cases of infection, ranging from an increase in sensitive markers for coagulation activation or insignificant laboratory changes to gross activation of coagulation that may result in localised thrombotic complications or disseminated intravascular coagulation. Systemic inflammation as a consequence of infection results in activation of coagulation, due to tissue factor-mediated thrombin generation, down-regulation of physiological anticoagulant mechanisms, and inhibition of fibrinolysis. Pro-inflammatory cytokines, immune cells and the endothelium form the interface on which differential effects on the coagulation and fibrinolysis pathways may ensue. Conversely, activation of the coagulation system may importantly affect inflammatory responses by direct and indirect mechanisms. Apart from the general coagulation response to inflammation associated with severe infection, specific infections may cause distinct features, such as haemorrhagic fever or thrombotic microangiopathy.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1872-9061
1872-9061