Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current

Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regulates the activity of many ion channels and other membrane-associated proteins. To determine precursor sources of the PM PI(4,5)P2 pool in tsA-201 cells, we monitored KCNQ2/3 channel currents and translocation of PHPLCδ1 doma...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 22; p. E2281
Main Authors:	Dickson, Eamonn J, Jensen, Jill B, Hille, Bertil
Format:	Journal Article
Language:	English
Published:	United States 03.06.2014
Subjects:	1-Phosphatidylinositol 4-Kinase - metabolism Androstadienes - pharmacology Cell Membrane - metabolism Cells, Cultured Golgi Apparatus - metabolism Humans KCNQ2 Potassium Channel - physiology KCNQ3 Potassium Channel - physiology Kidney - cytology Membrane Potentials - physiology Myosin Type II - metabolism Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphatidylinositols - metabolism Protein Kinase Inhibitors - pharmacology wortmannin pleckstrin homology domain phosphoinositides
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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