Significance of urinary tissue polypeptide specific antigen (TPS) determination in patients with urothelial carcinoma

Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (UTPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a r...

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Bibliographic Details
Published in:Anticancer research Vol. 15; no. 6B; p. 2819
Main Authors: Yao, W J, Chang, C J, Chan, S H, Chow, N H, Cheng, H L, Tzai, T S, Lin, S N
Format: Journal Article
Language:English
Published: Greece 01.11.1995
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - urine
Biomarkers, Tumor - urine
Carcinoma, Transitional Cell - diagnosis
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - urine
Female
Follow-Up Studies
Humans
Inflammation - urine
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local - urine
Peptides - urine
Predictive Value of Tests
Prognosis
Survival Rate
Urologic Diseases - urine
Urologic Neoplasms - diagnosis
Urologic Neoplasms - mortality
Urologic Neoplasms - urine
ISSN:0250-7005
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Summary:Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (UTPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.
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ISSN:0250-7005