Polycystic ovary syndrome, adipose tissue and metabolic syndrome

Purpose Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the...

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Vydáno v:Archives of gynecology and obstetrics Ročník 296; číslo 3; s. 405 - 419
Hlavní autoři: Delitala, Alessandro P., Capobianco, Giampiero, Delitala, Giuseppe, Cherchi, Pier Luigi, Dessole, Salvatore
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2017
Springer Nature B.V
Témata:
Adipokines
Adipose Tissue - metabolism
Adipose Tissue - pathology
Adipose Tissue - physiopathology
Adult
Androgens
Cardiovascular Diseases - complications
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Endocrinology
Female
Gynecology
Human Genetics
Humans
Insulin Resistance
Life Style
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - metabolism
Metabolic Syndrome - pathology
Obstetrics/Perinatology/Midwifery
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - pathology
Review
Polycystic ovary syndrome
Insulin resistance
Adipose tissue
Adipokines
Metabolic syndrome
ISSN:0932-0067, 1432-0711, 1432-0711
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Popis
Shrnutí:Purpose Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD). Methods A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome. Original articles, reviews, and meta-analysis were included. Results PCOS women are prone to visceral fat hypertrophy in the presence of androgen excess and the presence of these conditions is related to insulin resistance and worsens the PCO phenotype. Disturbed secretion of many adipocyte-derived substances (adipokines) is associated with chronic low-grade inflammation and contributes to insulin resistance. Abdominal obesity and insulin resistance stimulate ovarian and adrenal androgen production, and may further increase abdominal obesity and inflammation, thus creating a vicious cycle. Conclusion The high prevalence of metabolic disorders mainly related to insulin resistance and CVD risk factors in women with PCOS highlight the need for early lifestyle changes for reducing metabolic risks in these patients.
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ISSN:0932-0067
1432-0711
1432-0711
DOI:10.1007/s00404-017-4429-2