OSA, Short Sleep Duration, and Their Interactions With Sleepiness and Cardiometabolic Risk Factors in Adults: The ELSA-Brasil Study

OSA and short sleep duration (SSD) are frequently associated with daytime symptoms and cardiometabolic deregulation. However, the vast majority of studies addressing OSA have not evaluated SSD, and vice versa. Our aim was to evaluate the association of OSA, SSD, and their interactions with sleepines...

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Vydáno v:Chest Ročník 155; číslo 6; s. 1190
Hlavní autoři: Drager, Luciano F, Santos, Ronaldo B, Silva, Wagner A, Parise, Barbara K, Giatti, Soraya, Aielo, Aline N, Souza, Silvana P, Furlan, Sofia F, Lorenzi-Filho, Geraldo, Lotufo, Paulo A, Bensenor, Isabela M
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.2019
Témata:
Actigraphy - methods
Adult
Brazil - epidemiology
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Correlation of Data
Disorders of Excessive Somnolence - epidemiology
Disorders of Excessive Somnolence - psychology
Female
Humans
Longitudinal Studies
Male
Middle Aged
Obesity - epidemiology
Polysomnography - methods
Prevalence
Risk Factors
Severity of Illness Index
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - epidemiology
Sleep Deprivation - diagnosis
Sleep Deprivation - epidemiology
Sleep Deprivation - psychology
Surveys and Questionnaires
Wakefulness
Brazil
cardiovascular disease
epidemiology
sleep duration
risk factors
diagnosis
sleepiness
sleep apnea
ISSN:1931-3543, 1931-3543
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Shrnutí:OSA and short sleep duration (SSD) are frequently associated with daytime symptoms and cardiometabolic deregulation. However, the vast majority of studies addressing OSA have not evaluated SSD, and vice versa. Our aim was to evaluate the association of OSA, SSD, and their interactions with sleepiness and cardiometabolic risk factors in a large cohort of adults. Consecutive subjects from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) participated in clinical evaluations, sleep questionnaires, home sleep monitoring, and actigraphy. OSA was defined as an apnea-hypopnea index ≥ 15 events/hour. SSD was defined by a mean sleep duration < 6 h. Data from 2,064 participants were used in the final analysis (42.8% male; mean age, 49 ± 8 years). The overall frequency of OSA and SSD were 32.9% and 27.2%, respectively. Following an adjustment for multiple confounding factors, excessive daytime sleepiness was independently associated with SSD (OR, 1.448; 95% CI, 1.172-1.790) but not with OSA (OR, 1.107; 95% CI, 0.888-1.380). The SSD interaction with OSA was not significant. Prevalent obesity (OR, 3.894; 95% CI, 3.077-4.928), hypertension (OR, 1.314; 95% CI, 1.035-1.667), and dyslipidemia (OR, 1.251; 95% CI, 1.006-1.555) were independently associated with OSA but not with SSD. Similarly, the interactions of OSA with SSD were not significant. An additional analysis using < 5 h for SSD or continuous sleep duration did not change the lack of association with the cardiometabolic risk factors. Objective SSD but not OSA was independently associated with daytime sleepiness. By contrast, OSA, but not SSD, was independently associated with obesity, hypertension, and dyslipidemia.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1931-3543
1931-3543
DOI:10.1016/j.chest.2018.12.003