Targeting Regulated Cell Death with Pharmacological Small Molecules: An Update on Autophagy-Dependent Cell Death, Ferroptosis, and Necroptosis in Cancer

Regulated cell death is a widely attractive subject among the topics of cancer therapy and has gained some advances for discovery of targeted anticancer drugs. In the past decade, nonapoptotic regulated cell death has been implicated in the development and therapeutic responses of a variety of human...

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Veröffentlicht in:Journal of medicinal chemistry Jg. 65; H. 4; S. 2989
Hauptverfasser: Wu, Junhao, Ye, Jing, Xie, Qiang, Liu, Bo, Liu, Ming
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 24.02.2022
Schlagworte:
Antineoplastic Agents - pharmacology
Autophagic Cell Death - drug effects
Cell Death - drug effects
Ferroptosis - drug effects
Humans
Necroptosis - drug effects
Regulated Cell Death - drug effects
Small Molecule Libraries
ISSN:1520-4804, 1520-4804
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Zusammenfassung:Regulated cell death is a widely attractive subject among the topics of cancer therapy and has gained some advances for discovery of targeted anticancer drugs. In the past decade, nonapoptotic regulated cell death has been implicated in the development and therapeutic responses of a variety of human cancers. Hitherto, targeting autophagy-dependent cell death (ADCD), ferroptosis, and necroptosis with small molecules has been emerging as a hopeful strategy for the improvement of potential cancer therapy, which may have an advantage to bypass the apoptosis-resistance machinery. Thus, in this perspective, we concentrate on the key molecular insights into ADCD, ferroptosis, and necroptosis and summarize the corresponding small molecules in potential cancer therapy. Moreover, the relationships between the three subroutines and small molecules modulating the crosstalk are discussed. We believe that these inspiring findings would be advantageous to exploiting more potential targets and pharmacological small molecules in future cancer treatment.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1520-4804
1520-4804
DOI:10.1021/acs.jmedchem.1c01572