Targeting Regulated Cell Death with Pharmacological Small Molecules: An Update on Autophagy-Dependent Cell Death, Ferroptosis, and Necroptosis in Cancer

Regulated cell death is a widely attractive subject among the topics of cancer therapy and has gained some advances for discovery of targeted anticancer drugs. In the past decade, nonapoptotic regulated cell death has been implicated in the development and therapeutic responses of a variety of human...

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Vydané v:Journal of medicinal chemistry Ročník 65; číslo 4; s. 2989
Hlavní autori: Wu, Junhao, Ye, Jing, Xie, Qiang, Liu, Bo, Liu, Ming
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 24.02.2022
Predmet:
Antineoplastic Agents - pharmacology
Autophagic Cell Death - drug effects
Cell Death - drug effects
Ferroptosis - drug effects
Humans
Necroptosis - drug effects
Regulated Cell Death - drug effects
Small Molecule Libraries
ISSN:1520-4804, 1520-4804
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Popis
Shrnutí:Regulated cell death is a widely attractive subject among the topics of cancer therapy and has gained some advances for discovery of targeted anticancer drugs. In the past decade, nonapoptotic regulated cell death has been implicated in the development and therapeutic responses of a variety of human cancers. Hitherto, targeting autophagy-dependent cell death (ADCD), ferroptosis, and necroptosis with small molecules has been emerging as a hopeful strategy for the improvement of potential cancer therapy, which may have an advantage to bypass the apoptosis-resistance machinery. Thus, in this perspective, we concentrate on the key molecular insights into ADCD, ferroptosis, and necroptosis and summarize the corresponding small molecules in potential cancer therapy. Moreover, the relationships between the three subroutines and small molecules modulating the crosstalk are discussed. We believe that these inspiring findings would be advantageous to exploiting more potential targets and pharmacological small molecules in future cancer treatment.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1520-4804
1520-4804
DOI:10.1021/acs.jmedchem.1c01572