A clinical study to assess the gingivitis reduction efficacy of a novel stannous-containing fluoride dentifrice

To assess the gingivitis reduction efficacy of a novel stannous-containing fluoride dentifrice relative to a negative control. 100 generally healthy adults with 10 or more gingival bleeding sites based on the Mazza Modification of the Papillary Bleeding Index (Mazza GI) were enrolled into a 2-week r...

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Veröffentlicht in:American journal of dentistry Jg. 34; H. 2; S. 87
Hauptverfasser: Xu, Zhipeng, He, Tao, He, Yanyan, Fei, Phil, Sun, Lily, Chen, Yamei, Li, Jiahui
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.04.2021
Schlagworte:
Adult
Dentifrices - therapeutic use
Fluorides
Gingivitis - drug therapy
Gingivitis - prevention & control
Humans
Periodontal Index
Tin Fluorides - therapeutic use
ISSN:0894-8275
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Zusammenfassung:To assess the gingivitis reduction efficacy of a novel stannous-containing fluoride dentifrice relative to a negative control. 100 generally healthy adults with 10 or more gingival bleeding sites based on the Mazza Modification of the Papillary Bleeding Index (Mazza GI) were enrolled into a 2-week randomized, controlled, double-blind, single-center, two-treatment, parallel group clinical study. The subjects were randomly assigned to the stannous-containing dentifrice group (experimental group) or the sodium fluoride dentifrice group (negative control group). An oral examination and Mazza GI examination were conducted at Baseline, Day 3 and Week 2 post-baseline by a qualified dental examiner. 98 subjects completed the study. The experimental group provided a significant reduction in Mazza GI scores and number of bleeding sites relative to baseline at Day 3 and Week 2 (P< 0.0001). The negative control did not provide significant reductions versus baseline for either measure at either timepoint (P> 0.3). At Day 3, the experimental group provided a statistically significant reduction of Mazza GI scores and number of bleeding sites compared with the negative control group (P< 0.0001). At Week 2, the experimental group showed 24.11% lower Mazza GI scores and 54.81% fewer bleeding sites than the negative control group (P< 0.0001). The results demonstrated that the novel stannous-containing fluoride dentifrice had a superior anti-gingivitis effect compared to the sodium fluoride negative control dentifrice, which was evident as quickly as 3 days after use and further improved after 2 weeks of usage.
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ISSN:0894-8275