Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells

cAMP-PKA protein kinase is a key nodal signaling pathway that regulates a wide range of heart pacemaker cell functions. These functions are predicted to be involved in regulation of spontaneous action potential (AP) generation of these cells. Here we investigate if the kinetics and stoichiometry of...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology Vol. 86; p. 168
Main Authors:	Yaniv, Yael, Ganesan, Ambhighainath, Yang, Dongmei, Ziman, Bruce D, Lyashkov, Alexey E, Levchenko, Andre, Zhang, Jin, Lakatta, Edward G
Format:	Journal Article
Language:	English
Published:	England 01.09.2015
Subjects:	Action Potentials - drug effects Animals Calcium Signaling Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Humans Kinetics Phosphodiesterase Inhibitors - administration & dosage Phosphorylation - drug effects Rabbits Receptors, Adrenergic, beta - metabolism Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - pathology Signal Transduction - drug effects Sinoatrial Node - drug effects Sinoatrial Node - metabolism Sinoatrial Node - pathology Phosphorylation Computational modeling Pacemaker Coupled-clock system
ISSN:	1095-8584, 1095-8584
Online Access:	Get full text
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