Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

The RefSeq project at the National Center for Biotechnology Information (NCBI) maintains and curates a publicly available database of annotated genomic, transcript, and protein sequence records (http://www.ncbi.nlm.nih.gov/refseq/). The RefSeq project leverages the data submitted to the Internationa...

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Published in:Nucleic acids research Vol. 44; no. D1; pp. D733 - D745
Main Authors: O'Leary, Nuala A, Wright, Mathew W, Brister, J Rodney, Ciufo, Stacy, Haddad, Diana, McVeigh, Rich, Rajput, Bhanu, Robbertse, Barbara, Smith-White, Brian, Ako-Adjei, Danso, Astashyn, Alexander, Badretdin, Azat, Bao, Yiming, Blinkova, Olga, Brover, Vyacheslav, Chetvernin, Vyacheslav, Choi, Jinna, Cox, Eric, Ermolaeva, Olga, Farrell, Catherine M, Goldfarb, Tamara, Gupta, Tripti, Haft, Daniel, Hatcher, Eneida, Hlavina, Wratko, Joardar, Vinita S, Kodali, Vamsi K, Li, Wenjun, Maglott, Donna, Masterson, Patrick, McGarvey, Kelly M, Murphy, Michael R, O'Neill, Kathleen, Pujar, Shashikant, Rangwala, Sanjida H, Rausch, Daniel, Riddick, Lillian D, Schoch, Conrad, Shkeda, Andrei, Storz, Susan S, Sun, Hanzhen, Thibaud-Nissen, Francoise, Tolstoy, Igor, Tully, Raymond E, Vatsan, Anjana R, Wallin, Craig, Webb, David, Wu, Wendy, Landrum, Melissa J, Kimchi, Avi, Tatusova, Tatiana, DiCuccio, Michael, Kitts, Paul, Murphy, Terence D, Pruitt, Kim D
Format: Journal Article
Language:English
Published: England Oxford University Press 04.01.2016
Subjects:
Animals
Cattle
Database Issue
Databases, Genetic
Gene Expression Profiling
Genome, Fungal
Genome, Human
Genome, Microbial
Genome, Plant
Genome, Viral
Genomics - standards
Humans
Invertebrates - genetics
Mice
Molecular Sequence Annotation
Nematoda - genetics
Phylogeny
Rats
Reference Standards
RNA, Long Noncoding - genetics
Sequence Analysis, Protein
Sequence Analysis, RNA
Vertebrates - genetics
ISSN:1362-4962, 0305-1048, 1362-4962
Online Access:Get full text
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Summary:The RefSeq project at the National Center for Biotechnology Information (NCBI) maintains and curates a publicly available database of annotated genomic, transcript, and protein sequence records (http://www.ncbi.nlm.nih.gov/refseq/). The RefSeq project leverages the data submitted to the International Nucleotide Sequence Database Collaboration (INSDC) against a combination of computation, manual curation, and collaboration to produce a standard set of stable, non-redundant reference sequences. The RefSeq project augments these reference sequences with current knowledge including publications, functional features and informative nomenclature. The database currently represents sequences from more than 55,000 organisms (>4800 viruses, >40,000 prokaryotes and >10,000 eukaryotes; RefSeq release 71), ranging from a single record to complete genomes. This paper summarizes the current status of the viral, prokaryotic, and eukaryotic branches of the RefSeq project, reports on improvements to data access and details efforts to further expand the taxonomic representation of the collection. We also highlight diverse functional curation initiatives that support multiple uses of RefSeq data including taxonomic validation, genome annotation, comparative genomics, and clinical testing. We summarize our approach to utilizing available RNA-Seq and other data types in our manual curation process for vertebrate, plant, and other species, and describe a new direction for prokaryotic genomes and protein name management.
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ISSN:1362-4962
0305-1048
1362-4962
DOI:10.1093/nar/gkv1189