Local delivery of low-dose anti-CTLA-4 to the melanoma lymphatic basin leads to systemic Treg reduction and effector T cell activation

Preclinical studies show that locoregional CTLA-4 blockade is equally effective in inducing tumor eradication as systemic delivery, without the added risk of immune-related side effects. This efficacy is related to access of the CTLA-4 blocking antibodies to tumor-draining lymph nodes (TDLNs). Local...

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Veröffentlicht in:	Science immunology Jg. 7; H. 73; S. eabn8097
Hauptverfasser:	van Pul, Kim M, Notohardjo, Jessica C L, Fransen, Marieke F, Koster, Bas D, Stam, Anita G M, Chondronasiou, Dafni, Lougheed, Sinéad M, Bakker, Joyce, Kandiah, Vinitha, van den Tol, M Petrousjka, Jooss, Karin, Vuylsteke, Ronald J C L M, van den Eertwegh, Alfons J M, de Gruijl, Tanja D
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	01.07.2022
ISSN:	2470-9468, 2470-9468
Online-Zugang:	Weitere Angaben
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