BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice

Retinitis pigmentosa (RP) is a heterogeneous group of genetic disorders leading to blindness, which remain untreatable at present. Rd1 mice represent a recognized model of RP, and so far only GDNF treatment provided a slight delay in the retinal degeneration in these mice. Bmi1, a transcriptional re...

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Veröffentlicht in:	Advances in experimental medicine and biology Jg. 572; S. 209
Hauptverfasser:	Zencak, Dusan, Crippa, Sylvain V, Tekaya, Meriem, Tanger, Ellen, Schorderet, Daniel E, Munier, Francis L, van Lohuizen, Maarten, Arsenijevic, Yvan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 2006
Schlagworte:	Animals Cell Proliferation Disease Models, Animal Electroretinography Mice Mice, Knockout Mice, Transgenic Models, Biological Neuroglia - metabolism Neurons - cytology Neuroprotective Agents - pharmacology Nuclear Proteins - genetics Polycomb Repressive Complex 1 Proto-Oncogene Proteins - genetics Repressor Proteins - genetics Retina - metabolism Retinal Degeneration - genetics Retinal Degeneration - metabolism Stem Cells - cytology
ISSN:	0065-2598
Online-Zugang:	Weitere Angaben
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