Linking Expression of Cell-Surface Receptors with Transcription Factors by Computational Analysis of Paired Single-Cell Proteomes and Transcriptomes

Complex signaling and transcriptional programs control the development and physiology of specialized cell types. Genetic perturbations in these programs cause human cancers to arise from a diverse set of specialized cell types and developmental states. Understanding these complex systems and their p...

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Bibliographic Details
Published in:	Methods in molecular biology (Clifton, N.J.) Vol. 2660; p. 149
Main Authors:	Sagan, April, Ma, Xiaojun, Ramjattun, Koushul, Osmanbeyoglu, Hatice Ulku
Format:	Journal Article
Language:	English
Published:	United States 2023
Subjects:	Humans Leukocytes, Mononuclear Proteome Proteomics Single-Cell Analysis Transcription Factors - genetics Transcriptome Droplet-based scRNA-seq scVerse and Scanpy ecosystems Affinity regression (AR) scADT-seq Jupyter notebook pySPaRTAN package DoRothEA database Single-cell Proteomic and RNA-based Transcription factor Activity Network (SPaRTAN) Python package Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) Antibody-derived tags (ADTs)
ISSN:	1940-6029, 1940-6029
Online Access:	Get more information
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