Outlier Analysis and Top Scoring Pairfor Integrated Data Analysisand Biomarker Discovery

Pathway deregulation has been identified as a key driver of carcinogenesis, with proteins in signaling pathways serving as primary targets for drug development. Deregulation can be driven by a number of molecular events, including gene mutation, epigenetic changes in gene promoters, overexpression,...

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Veröffentlicht in:	IEEE/ACM transactions on computational biology and bioinformatics Jg. 11; H. 3; S. 520 - 532
Hauptverfasser:	Ochs, Michael F, Farrar, Jason E, Considine, Michael, Wei, Yingying, Meshinchi, Soheil, Arceci, Robert J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 01.05.2014
Schlagworte:	Algorithms Biomarkers Carcinogens Deregulation Drugs Genes Medical treatment Pathways Pediatrics Tumors
ISSN:	1545-5963, 1557-9964
Online-Zugang:	Volltext
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