Micro machining of micro-cantilever probes for efficient deposition for biochips

Biochip technology will bring a tremendous revolution to life science and medical research in 21 century. Microarray assays represent an essential technical advance in biomedical research. Recently, the demand for microarray assay technology has spring up. Therefore, low cost and flexible techniques...

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Veröffentlicht in:Shengwu gongcheng xuebao Jg. 21; H. 2; S. 227
Hauptverfasser: Li, Yong-Hai, Ding, Gui-Fu, Xu, Jun-Tao, Zhang, Yong-Hua
Format: Journal Article
Sprache:Chinesisch
Veröffentlicht: China 01.03.2005
Schlagworte:
Microarray Analysis - instrumentation
Microarray Analysis - methods
Microelectrodes
Molecular Probe Techniques - instrumentation
Nanotechnology - instrumentation
Nanotechnology - methods
Silicon Dioxide - chemistry
ISSN:1000-3061
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Zusammenfassung:Biochip technology will bring a tremendous revolution to life science and medical research in 21 century. Microarray assays represent an essential technical advance in biomedical research. Recently, the demand for microarray assay technology has spring up. Therefore, low cost and flexible techniques are needed to meet specific requirements for increasingly integrated biochips. Also performance must be improved in terms of speed and sensitivity. To this end, promising approaches, mainly based on micro and nanotechnologies, have been developed. In this paper, the design and microfabrication of a novel type of micro-cantilever probe are introduced. These probes were fabricated using silicon dioxide by Micro-electromechanical System (MEMS) techniques, and they featured one micron split gap, microchannels and self-replenishing reservoirs. All fabricated micro-cantilever probe were tested on Nanoarrayer instrumentation. Cy3-streptavidin was loaded as biological sample and patterned on DSU gold surface. Results show
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ISSN:1000-3061