Prevalence of dyslipidemia in middle-aged adults with NOS3 gene polymorphism and low cardiorespiratory fitness

To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786T>C, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disord...

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Vydané v:Arquivos brasileiros de endocrinologia e metabologia Ročník 57; číslo 1; s. 33
Hlavní autori: Malagrino, Pamella A, Sponton, Carlos H G, Esposti, Rodrigo D, Franco-Penteado, Carla F, Fernandes, Romulo A, Bezerra, Marcos André C, Albuquerque, Dulcinéia M, Rodovalho, Cynara M, Bacci, Maurício, Zanesco, Angelina
Médium: Journal Article
Jazyk:Portuguese
Vydavateľské údaje: Brazil 01.02.2013
Predmet:
Cardiovascular System - physiopathology
Cholesterol - blood
Dyslipidemias - blood
Dyslipidemias - epidemiology
Dyslipidemias - genetics
Epidemiologic Methods
Female
Genotype
Glutamic Acid - genetics
Humans
Introns - genetics
Male
Middle Aged
Nitrates - blood
Nitric Oxide Synthase Type III - genetics
Nitrites - blood
Oxygen Consumption - genetics
Polymorphism, Genetic - genetics
Promoter Regions, Genetic - genetics
Respiratory System - physiopathology
ISSN:1677-9487, 1677-9487
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Shrnutí:To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786T>C, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disorders. Ninety-two volunteers were genotyped for NOS3 polymorphisms at positions (-786T>C and Glu298Asp) and (intron 4b/a) and divided according to the genotype: non-polymorphic (NP) and polymorphic (P). After that, they were subdivided according to the cardiorespiratory fitness associated with genotype: high (HNP and HP) and low (LNP and LP). The subjects with polymorphism for the interactions at positions Glu298Asp + intron 4b/a, and Glu298Asp+-786T>C showed the highest values in total cholesterol, as well as dyslipidemia. Our findings show that NOS3 gene polymorphisms at positions -786T>C, Glu298Asp, and intron 4b/a exert negative effects on the lipid profile compared with those who do not carry polymorphisms.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1677-9487
1677-9487
DOI:10.1590/S0004-27302013000100005