Metastatic screening before adjuvant chemotherapy in breast cancer

Systematic metastasis staging in early breast cancer is no longer recommended. However, it is still performed before adjuvant chemotherapy. We assessed metastasis screening of asymptomatic women with a local breast cancer without lymph node involvement when adjuvant chemotherapy was indicated. The s...

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Bibliographic Details
Published in:Bulletin du cancer Vol. 102; no. 5; p. 411
Main Authors: Thonnon, Cyrielle, Faure, Christelle, Chopin, Nicolas, Beurrier, Frédéric, Ho Quoc, Christophe, Tredan, Olivier, Carrabin, Nicolas
Format: Journal Article
Language:French
Published: France 01.05.2015
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Chemotherapy, Adjuvant
Female
Humans
Lymph Nodes
Lymphatic Metastasis
Middle Aged
Retrospective Studies
Bilan d’extension
Medical research
Métastase
Bibliometrics
Faux positif
Cancer du sein
Breast cancer
Bibliographic database
Chimiothérapie
Non-envahissement ganglionnaire
France
ISSN:1769-6917, 1769-6917
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Summary:Systematic metastasis staging in early breast cancer is no longer recommended. However, it is still performed before adjuvant chemotherapy. We assessed metastasis screening of asymptomatic women with a local breast cancer without lymph node involvement when adjuvant chemotherapy was indicated. The screening result was classified in 3 groups: "non-metastatic", "metastatic" and "suspect". For suspect screening, we analyzed the checking period and the consequences on cares. Out of 1545 patients with possible indication of chemotherapy, 690 indications of chemotherapy were validated by multidisciplinary meeting. Six hundred and thirty-nine metastasis screening were done. Five hundred and fifty-five screenings (86.9 %) were "non-metastatic", 3 screenings (0.5 %) were "metastatic" and 81 screenings (12.7 %) were "suspect". Out of this 81 suspect screening, only 47 screening have been checked, using 61 further investigations. No breast cancer metastasis was finally identified. Low rate of metastasis suggest reassessing metastasis screening before adjuvant chemotherapy for patients without lymph node involvement.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1769-6917
1769-6917
DOI:10.1016/j.bulcan.2015.02.018