Placental expression of adenosine A(2A) receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system

Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A2AR receptor and HIF-1α in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. R...

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Bibliographic Details
Published in:Placenta (Eastbourne) Vol. 36; no. 5; pp. 611 - 613
Main Authors: Kurlak, L O, Williams, P J, Bulmer, J N, Broughton Pipkin, F, Mistry, H D
Format: Journal Article
Language:English
Published: Netherlands 01.05.2015
Subjects:
Case-Control Studies
Female
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Placenta - metabolism
Pre-Eclampsia - metabolism
Pregnancy
Pregnancy Trimester, First - metabolism
Receptor, Adenosine A2A - metabolism
Receptors, Angiotensin - metabolism
Renin-Angiotensin System
Early pregnancy
Placental A2AR
Pre-eclampsia
HIF-1α: angiotensin receptors
ISSN:1532-3102
Online Access:Get full text
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Summary:Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A2AR receptor and HIF-1α in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. Results were compared to our previously reported angiotensin receptor data. Expression of A2AR and HIF-1α was highest at ≤10 weeks, positively correlated through pregnancy and was higher in PE than NT at delivery. The A2AR associated with the AT4R only in early pregnancy. We suggest adenosine and RAS may interact to promote placentation with a potential adaptation to poor placental perfusion in PE.
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ISSN:1532-3102
DOI:10.1016/j.placenta.2015.02.011