Photogenerator of trichloroacetic acid--a perspective detritylation agent for microchip oligonucleotide synthesis

For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating tri...

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Veröffentlicht in:	Bioorganicheskaia khimiia Jg. 40; H. 5; S. 636
Hauptverfasser:	Siniakov, A N, Nikolaenkova, E B, Os'kina, I A, Savel'ev, V A, Samsonov, V A, Tikhonov, A Ia, Palatkina, M Iu, Zaĭtsev, D E
Format:	Journal Article
Sprache:	Russisch
Veröffentlicht:	Russia (Federation) 01.09.2014
Schlagworte:	Kinetics Light Microchip Analytical Procedures Molecular Structure Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Trichloroacetic Acid - chemical synthesis Trichloroacetic Acid - chemistry
ISSN:	0132-3423
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Zusammenfassung:	For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.
Bibliographie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0132-3423
DOI:	10.7868/s0132342314050121