Simultaneous Mapping of T 1 and T 2 Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T

Cardiac MR fingerprinting (cMRF) is a novel technique for simultaneous T and T mapping. To compare T /T measurements, repeatability, and map quality between cMRF and standard mapping techniques in healthy subjects. Prospective. In all, 58 subjects (ages 18-60). FIELD STRENGTH/SEQUENCE: cMRF, modifie...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance imaging Vol. 52; no. 4; p. 1044
Main Authors: Hamilton, Jesse I, Pahwa, Shivani, Adedigba, Joseph, Frankel, Samuel, O'Connor, Gregory, Thomas, Rahul, Walker, Jonathan R, Killinc, Ozden, Lo, Wei-Ching, Batesole, Joshua, Margevicius, Seunghee, Griswold, Mark, Rajagopalan, Sanjay, Gulani, Vikas, Seiberlich, Nicole
Format: Journal Article
Language:English
Published: United States 01.10.2020
Subjects:
Adolescent
Adult
Healthy Volunteers
Heart - diagnostic imaging
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Middle Aged
Phantoms, Imaging
Prospective Studies
Reproducibility of Results
Young Adult
spiral
magnetic resonance fingerprinting
relaxation times
parameter mapping
ISSN:1522-2586
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiac MR fingerprinting (cMRF) is a novel technique for simultaneous T and T mapping. To compare T /T measurements, repeatability, and map quality between cMRF and standard mapping techniques in healthy subjects. Prospective. In all, 58 subjects (ages 18-60). FIELD STRENGTH/SEQUENCE: cMRF, modified Look-Locker inversion recovery (MOLLI), and T -prepared balanced steady-state free precession (bSSFP) at 1.5T. T /T values were measured in 16 myocardial segments at apical, medial, and basal slice positions. Test-retest and intrareader repeatability were assessed for the medial slice. cMRF and conventional mapping sequences were compared using ordinal and two alternative forced choice (2AFC) ratings. Paired t-tests, Bland-Altman analyses, intraclass correlation coefficient (ICC), linear regression, one-way analysis of variance (ANOVA), and binomial tests. Average T measurements were: basal 1007.4±96.5 msec (cMRF), 990.0±45.3 msec (MOLLI); medial 995.0±101.7 msec (cMRF), 995.6±59.7 msec (MOLLI); apical 1006.6±111.2 msec (cMRF); and 981.6±87.6 msec (MOLLI). Average T measurements were: basal 40.9±7.0 msec (cMRF), 46.1±3.5 msec (bSSFP); medial 41.0±6.4 msec (cMRF), 47.4±4.1 msec (bSSFP); apical 43.5±6.7 msec (cMRF), 48.0±4.0 msec (bSSFP). A statistically significant bias (cMRF T larger than MOLLI T ) was observed in basal (17.4 msec) and apical (25.0 msec) slices. For T , a statistically significant bias (cMRF lower than bSSFP) was observed for basal (-5.2 msec), medial (-6.3 msec), and apical (-4.5 msec) slices. Precision was lower for cMRF-the average of the standard deviation measured within each slice was 102 msec for cMRF vs. 61 msec for MOLLI T , and 6.4 msec for cMRF vs. 4.0 msec for bSSFP T . cMRF and conventional techniques had similar test-retest repeatability as quantified by ICC (0.87 cMRF vs. 0.84 MOLLI for T ; 0.85 cMRF vs. 0.85 bSSFP for T ). In the ordinal image quality comparison, cMRF maps scored higher than conventional sequences for both T (all five features) and T (four features). This work reports on myocardial T /T measurements in healthy subjects using cMRF and standard mapping sequences. cMRF had slightly lower precision, similar test-retest and intrareader repeatability, and higher scores for map quality. 2 TECHNICAL EFFICACY: Stage 1 J. Magn. Reson. Imaging 2020;52:1044-1052.
ISSN:1522-2586
DOI:10.1002/jmri.27155