A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

In a randomized trial, 48 weeks of treatment with bulevirtide, which inhibits hepatitis D virus entry into hepatocytes, reduced HDV RNA and alanine aminotransferase levels in patients with chronic hepatitis D.

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Vydané v:The New England journal of medicine Ročník 389; číslo 1; s. 22 - 32
Hlavní autori: Wedemeyer, Heiner, Aleman, Soo, Brunetto, Maurizia Rossana, Blank, Antje, Andreone, Pietro, Bogomolov, Pavel, Chulanov, Vladimir, Mamonova, Nina, Geyvandova, Natalia, Morozov, Viacheslav, Sagalova, Olga, Stepanova, Tatyana, Berger, Annemarie, Manuilov, Dmitry, Suri, Vithika, An, Qi, Da, Ben, Flaherty, John, Osinusi, Anu, Liu, Yang, Merle, Uta, Schulze zur Wiesch, Julian, Zeuzem, Stefan, Ciesek, Sandra, Cornberg, Markus, Lampertico, Pietro
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Massachusetts Medical Society 06.07.2023
Predmet:
Alanine transaminase
Antiviral Agents - administration & dosage
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
Antiviral drugs
Arthralgia
Asthenia
Biopsy
Cirrhosis
Coinfection - drug therapy
Coinfection - virology
Disease
Eosinophilia
FDA approval
Gastroenterology
Gastroenterology General
Hepatitis B
Hepatitis B surface antigen
Hepatitis B Surface Antigens
Hepatitis B virus - genetics
Hepatitis B, Chronic - drug therapy
Hepatitis D, Chronic - drug therapy
Hepatitis delta virus
Hepatitis Delta Virus - genetics
Hepatocytes
Humans
Infections
Infectious Disease
Infectious Disease General
Interferon
Liver cirrhosis
Liver Disease
Liver diseases
Pruritus
Ribonucleic acid
RNA
Viral Infections
Russia
ISSN:0028-4793, 1533-4406, 1533-4406
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Popis
Shrnutí:In a randomized trial, 48 weeks of treatment with bulevirtide, which inhibits hepatitis D virus entry into hepatocytes, reduced HDV RNA and alanine aminotransferase levels in patients with chronic hepatitis D.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Undefined-1
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa2213429