Multiorgan and Renal Tropism of SARS-CoV-2

In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 383; no. 6; pp. 590 - 592
Main Authors: Puelles, Victor G, Lütgehetmann, Marc, Lindenmeyer, Maja T, Sperhake, Jan P, Wong, Milagros N, Allweiss, Lena, Chilla, Silvia, Heinemann, Axel, Wanner, Nicola, Liu, Shuya, Braun, Fabian, Lu, Shun, Pfefferle, Susanne, Schröder, Ann S, Edler, Carolin, Gross, Oliver, Glatzel, Markus, Wichmann, Dominic, Wiech, Thorsten, Kluge, Stefan, Pueschel, Klaus, Aepfelbacher, Martin, Huber, Tobias B
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 06.08.2020
Subjects:
Aged
Aged, 80 and over
Autopsy
Betacoronavirus - isolation & purification
Betacoronavirus - physiology
Brain - virology
Brain research
Coronavirus Infections
Coronaviruses
Correspondence
COVID-19
Female
Heart - virology
Humans
Kidney - virology
Kidneys
Liver - virology
Lung - virology
Male
Middle Aged
Organotropism
Pandemics
Pharynx - virology
Pneumonia, Viral
Respiratory tract
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Tropism
Viral Load
Viral Tropism
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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Drs. Puelles, Lütgehetmann, Lindenmeyer, and Sperhake contributed equally to this letter.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc2011400