Multiorgan and Renal Tropism of SARS-CoV-2
In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions.
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| Published in: | The New England journal of medicine Vol. 383; no. 6; pp. 590 - 592 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Massachusetts Medical Society
06.08.2020
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| ISSN: | 0028-4793, 1533-4406, 1533-4406 |
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| Abstract | In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions. |
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| AbstractList | In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brain. They speculate that organotropism influences the course of Covid-19 disease and, possibly, aggravates preexisting conditions. |
| Author | Sperhake, Jan P Kluge, Stefan Liu, Shuya Schröder, Ann S Allweiss, Lena Wong, Milagros N Chilla, Silvia Edler, Carolin Gross, Oliver Lindenmeyer, Maja T Huber, Tobias B Puelles, Victor G Lütgehetmann, Marc Heinemann, Axel Aepfelbacher, Martin Pueschel, Klaus Pfefferle, Susanne Wichmann, Dominic Wiech, Thorsten Wanner, Nicola Lu, Shun Glatzel, Markus Braun, Fabian |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32402155$$D View this record in MEDLINE/PubMed |
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| DOI | 10.1056/NEJMc2011400 |
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| Notes | SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 14 ObjectType-Article-2 content type line 23 Drs. Puelles, Lütgehetmann, Lindenmeyer, and Sperhake contributed equally to this letter. |
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| References | Pei, G, Zhang, Z, Peng, J (r005) Su, H, Yang, M, Wan, C (r004) r001 Zou, L, Ruan, F, Huang, M (r002) 2020; 382 Sungnak, W, Huang, N, Bécavin, C (r003) |
| References_xml | – ident: r003 article-title: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. publication-title: Nat Med – ident: r005 article-title: Renal involvement and early prognosis in patients with COVID-19 pneumonia. publication-title: J Am Soc Nephrol – volume: 382 start-page: 1177 year: 2020 end-page: 1179 ident: r002 article-title: SARS-CoV-2 viral load in upper respiratory specimens of infected patients. publication-title: N Engl J Med – ident: r001 article-title: Coronavirus disease 2019 (COVID-2019): situation report — 51. Geneva: World Health Organization, 2020 ( https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf ) – ident: r004 article-title: Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. publication-title: Kidney Int |
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| SubjectTerms | Aged Aged, 80 and over Autopsy Betacoronavirus - isolation & purification Betacoronavirus - physiology Brain - virology Brain research Coronavirus Infections Coronaviruses Correspondence COVID-19 Female Heart - virology Humans Kidney - virology Kidneys Liver - virology Lung - virology Male Middle Aged Organotropism Pandemics Pharynx - virology Pneumonia, Viral Respiratory tract SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Tropism Viral Load Viral Tropism |
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| Title | Multiorgan and Renal Tropism of SARS-CoV-2 |
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