Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women

Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in ci...

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Veröffentlicht in:The New England journal of medicine Jg. 385; H. 7; S. 595 - 608
Hauptverfasser: Landovitz, Raphael J, Donnell, Deborah, Clement, Meredith E, Hanscom, Brett, Cottle, Leslie, Coelho, Lara, Cabello, Robinson, Chariyalertsak, Suwat, Dunne, Eileen F, Frank, Ian, Gallardo-Cartagena, Jorge A, Gaur, Aditya H, Gonzales, Pedro, Tran, Ha V, Hinojosa, Juan C, Kallas, Esper G, Kelley, Colleen F, Losso, Marcelo H, Madruga, J. Valdez, Middelkoop, Keren, Phanuphak, Nittaya, Santos, Breno, Sued, Omar, Valencia Huamaní, Javier, Overton, Edgar T, Swaminathan, Shobha, del Rio, Carlos, Gulick, Roy M, Richardson, Paul, Sullivan, Philip, Piwowar-Manning, Estelle, Marzinke, Mark, Hendrix, Craig, Li, Maoji, Wang, Zhe, Marrazzo, Jeanne, Daar, Eric, Asmelash, Aida, Brown, Todd T, Anderson, Peter, Eshleman, Susan H, Bryan, Marcus, Blanchette, Cheryl, Lucas, Jonathan, Psaros, Christina, Safren, Steven, Sugarman, Jeremy, Scott, Hyman, Eron, Joseph J, Fields, Sheldon D, Sista, Nirupama D, Gomez-Feliciano, Kailazarid, Jennings, Andrea, Kofron, Ryan M, Holtz, Timothy H, Shin, Katherine, Rooney, James F, Smith, Kimberly Y, Spreen, William, Margolis, David, Rinehart, Alex, Adeyeye, Adeola, Cohen, Myron S, McCauley, Marybeth, Grinsztejn, Beatriz
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 12.08.2021
Schlagworte:
Acquired immune deficiency syndrome
Administration, Oral
Adult
Aged
AIDS
Allergies
Anti-HIV Agents - therapeutic use
Antigens
Antiretroviral drugs
Cisgender
Delayed-Action Preparations - administration & dosage
Disease prevention
Dosage
Double-Blind Method
Double-blind studies
Drug Administration Schedule
Drug dosages
Drug Resistance - genetics
Emtricitabine
Female
Gays & lesbians
Global Health
Hepatitis
HIV
HIV Infections - prevention & control
HIV Integrase Inhibitors - administration & dosage
HIV Integrase Inhibitors - adverse effects
Homosexuality, Male
Human immunodeficiency virus
Humans
Infections
Infectious Disease
Infectious diseases
Injections, Intramuscular - adverse effects
Integrase
Intention to Treat Analysis
Laboratories
Male
Medication Adherence
Mens health
Middle Aged
Plasma
Pre-Exposure Prophylaxis
Prophylaxis
Pyridones - administration & dosage
Pyridones - adverse effects
Tenofovir
Tenofovir - therapeutic use
Transgender Persons
Womens health
Young Adult
ISSN:0028-4793, 1533-4406, 1533-4406
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa2101016