Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women

Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in ci...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 385; no. 7; pp. 595 - 608
Main Authors:	Landovitz, Raphael J, Donnell, Deborah, Clement, Meredith E, Hanscom, Brett, Cottle, Leslie, Coelho, Lara, Cabello, Robinson, Chariyalertsak, Suwat, Dunne, Eileen F, Frank, Ian, Gallardo-Cartagena, Jorge A, Gaur, Aditya H, Gonzales, Pedro, Tran, Ha V, Hinojosa, Juan C, Kallas, Esper G, Kelley, Colleen F, Losso, Marcelo H, Madruga, J. Valdez, Middelkoop, Keren, Phanuphak, Nittaya, Santos, Breno, Sued, Omar, Valencia Huamaní, Javier, Overton, Edgar T, Swaminathan, Shobha, del Rio, Carlos, Gulick, Roy M, Richardson, Paul, Sullivan, Philip, Piwowar-Manning, Estelle, Marzinke, Mark, Hendrix, Craig, Li, Maoji, Wang, Zhe, Marrazzo, Jeanne, Daar, Eric, Asmelash, Aida, Brown, Todd T, Anderson, Peter, Eshleman, Susan H, Bryan, Marcus, Blanchette, Cheryl, Lucas, Jonathan, Psaros, Christina, Safren, Steven, Sugarman, Jeremy, Scott, Hyman, Eron, Joseph J, Fields, Sheldon D, Sista, Nirupama D, Gomez-Feliciano, Kailazarid, Jennings, Andrea, Kofron, Ryan M, Holtz, Timothy H, Shin, Katherine, Rooney, James F, Smith, Kimberly Y, Spreen, William, Margolis, David, Rinehart, Alex, Adeyeye, Adeola, Cohen, Myron S, McCauley, Marybeth, Grinsztejn, Beatriz
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 12.08.2021
Subjects:	Acquired immune deficiency syndrome Administration, Oral Adult Aged AIDS Allergies Anti-HIV Agents - therapeutic use Antigens Antiretroviral drugs Cisgender Delayed-Action Preparations - administration & dosage Disease prevention Dosage Double-Blind Method Double-blind studies Drug Administration Schedule Drug dosages Drug Resistance - genetics Emtricitabine Female Gays & lesbians Global Health Hepatitis HIV HIV Infections - prevention & control HIV Integrase Inhibitors - administration & dosage HIV Integrase Inhibitors - adverse effects Homosexuality, Male Human immunodeficiency virus Humans Infections Infectious Disease Infectious diseases Injections, Intramuscular - adverse effects Integrase Intention to Treat Analysis Laboratories Male Medication Adherence Mens health Middle Aged Plasma Pre-Exposure Prophylaxis Prophylaxis Pyridones - administration & dosage Pyridones - adverse effects Tenofovir Tenofovir - therapeutic use Transgender Persons Womens health Young Adult
ISSN:	0028-4793, 1533-4406, 1533-4406
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Summary:	Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2101016